Urinary homovanillic and vanillylmandelic acid in the diagnosis of neuroblastoma: Report from the Italian Cooperative Group for Neuroblastoma
| Autor: | Laura Barbagallo, Angelo Maffia, Massimo Conte, Giorgio Reggiardo, Stefania Sorrentino, Elisabetta Viscardi, Giuliana Cangemi, Alberto Garaventa, Iulian Gennai, Barbara Galleni, Valerio Cecinati, Francesco De Leonardis, Sebastiano Barco |
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| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Urinary system Clinical Biochemistry Urology Neuroendocrine tumors Neuroblastoma Vanilmandelic Acid Young Adult chemistry.chemical_compound Reference Values Internal medicine Biomarkers Tumor Humans Medicine Cooperative group Vanillylmandelic acid Stage (cooking) Child Receiver operating characteristic business.industry Homovanillic acid Infant Newborn Infant Homovanillic Acid General Medicine medicine.disease Endocrinology Italy ROC Curve chemistry Case-Control Studies Child Preschool Female business |
| Zdroj: | Clinical Biochemistry. 47:848-852 |
| ISSN: | 0009-9120 |
| Popis: | Background Urinary homovanillic and vanillylmandelic acid (HVA and VMA) are well known biomarkers for the management of neuroblastoma (NB). Very few and contradictory publications on their diagnostic performance are present in the literature. The aim of this study is to review the results of HVA/Cr and VMA/Cr obtained by the reference laboratory of the Italian Cooperative Group for NB within a 7-year period using HPLC-EC. Procedure Updated reference intervals based on age as a continuous variable were calculated by using a multivariate statistical analysis. The diagnostic performance of the two biomarkers has been established by calculating their specificity and sensitivity and by receiver operating characteristics (ROC) curves for different ages and stages of disease. Results Accurate age-related reference intervals were obtained from 648 HVA/Cr and 671 VMA/Cr results derived from patients in which the diagnosis of neuroendocrine tumors was excluded. Sensitivity, specificity and ROC curves were obtained from 169 HVA/Cr and 179 VMA/Cr results from confirmed NB patients. The best diagnostic performance was obtained in stage 4S tumors and in children Conclusions This is the first report, to our knowledge, that analyzes in depth the diagnostic performance of HVA/Cr and VMA/Cr for NB in different stages and age subgroups. In addition, the present work provides cut-off points able to discriminate between NB patients and negative subjects suspected to have NB and could be of help in taking medical decisions. |
| Databáze: | OpenAIRE |
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