Atg12–Atg3 Coordinates Basal Autophagy, Endolysosomal Trafficking, and Exosome Release

Autor:	Lyndsay M. Murrow, Jayanta Debnath
Rok vydání:	2018
Předmět:	0301 basic medicine Cancer Research Chemistry Autophagy Exosome Cell biology ATG12 Author's Views 03 medical and health sciences Basal (phylogenetics) 030104 developmental biology PROGRAMMED CELL DEATH 6-INTERACTING PROTEIN Cancer research Molecular Medicine Late endosome
Zdroj:	Molecular & Cellular Oncology. 5:e1039191
ISSN:	2372-3556
DOI:	10.1080/23723556.2015.1039191
Popis:	We recently identified an interaction between Atg12–Atg3, a complex between 2 core autophagy regulators, and the ESCRT-associated protein Pdcd6ip (programmed cell death 6 interacting protein, commonly known as Alix), which coordinately regulates basal autophagy, late endosome-to-lysosome trafficking, and exosome release. Because these processes all serve fundamental roles in cancer progression and therapy, Atg12-Atg3 may be an attractive anticancer target.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd387e7b8bd6a83cc0d4f9a43ae01bb7 https://doi.org/10.1080/23723556.2015.1039191 Zobrazit plný text záznamu