Exploring the utility of a novel point‐of‐care whole blood thrombin generation assay following trauma: A pilot study
| Autor: | Erica A. Loomis, Grant M. Spears, Stephanie F. Heller, Kent R. Bailey, Kenneth G. Mann, Taleen A. MacArthur, Daniel Stephens, Joseph M. Immermann, Michael Ferrara, Myung S. Park, Rosemary A. Kozar, Saulius Butenas |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
venous thromboembolism Thrombin generation Thrombin Lag time Interquartile range Internal medicine medicine plasma Point of care Whole blood lcsh:RC633-647.5 business.industry lcsh:Diseases of the blood and blood-forming organs calibrated Hematology thrombin trauma Original Articles ‐ Hemostasis kinetics Cardiology Time to peak Original Article business Venous thromboembolism medicine.drug |
| Zdroj: | Research and Practice in Thrombosis and Haemostasis Research and Practice in Thrombosis and Haemostasis, Vol 5, Iss 3, Pp 395-402 (2021) |
| ISSN: | 2475-0379 |
| DOI: | 10.1002/rth2.12483 |
| Popis: | Introduction Plasma thrombin generation kinetics as measured by the calibrated automated thrombogram (CAT) assay is a predictor of symptomatic venous thromboembolism after trauma. We hypothesized that data from a new prototype assay for measurement of thrombin generation kinetics in fresh whole blood (near patient testing of thrombin generation), will correlate with the standard CAT assay in the same patients, making it a potential tool in the future care of trauma patients. Methods Patients were enrolled from June 2018 to February 2020. Within 12 hours of injury, blood samples were collected simultaneously for both assays. Variables compared and correlated between assays were lag time, peak height, time to peak, and endogenous thrombin potential. Data are presented as median with interquartile range (IQR). Spearman and Pearson correlations were estimated and tested between both assays; a P value of |
| Databáze: | OpenAIRE |
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