The multiple functions of the numerous Chlamydia trachomatis secreted proteins: the tip of the iceberg
| Autor: | Luís Jaime Mota, Joana N. Bugalhão |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0209 industrial biotechnology
Chlamydiae Chlamydia trachomatis 02 engineering and technology Review Biology medicine.disease_cause Biochemistry Genetics and Molecular Biology (miscellaneous) Microbiology Applied Microbiology and Biotechnology 020901 industrial engineering & automation Immune system type III secretion Virology protein secretion 0202 electrical engineering electronic engineering information engineering Genetics medicine host-pathogen interactions Secretion lcsh:QH301-705.5 Molecular Biology Innate immune system Effector 020208 electrical & electronic engineering Cell Biology biology.organism_classification Cell biology Secretory protein lcsh:Biology (General) Host cell cytoplasm Parasitology effectors |
| Zdroj: | Microbial Cell Microbial Cell, Vol 6, Iss 9, Pp 414-449 (2019) |
| ISSN: | 2311-2638 |
| Popis: | Chlamydia trachomatis serovars are obligate intracellular bacterial pathogens mainly causing ocular and urogenital infections that affect millions of people worldwide and which can lead to blindness or sterility. They reside and multiply intracellularly within a membrane-bound vacuolar compartment, known as inclusion, and are characterized by a developmental cycle involving two morphologically and physiologically distinct chlamydial forms. Completion of the developmental cycle involves the secretion of > 70 C. trachomatis proteins that function in the host cell cytoplasm and nucleus, in the inclusion membrane and lumen, and in the extracellular milieu. These proteins can, for example, interfere with the host cell cytoskeleton, vesicular and non-vesicular transport, metabolism, and immune signalling. Generally, this promotes C. trachomatis invasion into, and escape from, host cells, the acquisition of nutrients by the chlamydiae, and evasion of cell-autonomous, humoral and cellular innate immunity. Here, we present an in-depth review on the current knowledge and outstanding questions about these C. trachomatis secreted proteins. |
| Databáze: | OpenAIRE |
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