Effects of reserpine on the plus-maze discriminative avoidance task: Dissociation between memory and motor impairments
| Autor: | Lúcia Garcez-do-Carmo, Rita C. Carvalho, Roberto Frussa-Filho, André L. Takatsu-Coleman, Sonia R. Kameda, Regina H. Silva, Camilla C. Patti, Vanessa C. Abílio, Claudio F. Souza |
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| Rok vydání: | 2006 |
| Předmět: |
Male
Reserpine Dissociation (neuropsychology) Motor Activity Discrimination Learning Mice Parkinsonian Disorders Avoidance Learning medicine Animals Memory impairment Memory disorder Maze Learning Molecular Biology Analysis of Variance Memory Disorders Adrenergic Uptake Inhibitors Dose-Response Relationship Drug General Neuroscience Memoria Cognitive disorder Cognition Body movement medicine.disease Disease Models Animal Neurology (clinical) Psychology Neuroscience Developmental Biology medicine.drug |
| Zdroj: | Brain Research. 1122:179-183 |
| ISSN: | 0006-8993 |
| Popis: | We investigated the effects of reserpine (0.1-0.5 mg/kg) on the performance of mice in the plus-maze discriminative avoidance task (DAVT), which simultaneously evaluates memory and motor activity. All doses induced memory impairment (increased aversive arm time) but only 0.5 mg/kg reserpine decreased locomotion (entries in enclosed arms). The results suggest that the DAVT evaluation in reserpine-treated mice can be a useful model for studying cognitive deficits accompanied by motor impairments. |
| Databáze: | OpenAIRE |
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