COLD LYMPHOCYTOTOXINS: AN IMPORTANT CAUSE OF ACUTE TUBULAR NECROSIS OCCURRING IMMEDIATELY AFTER TRANSPLANTATION
| Autor: | FrederickB. Westervelt, PeterI. Lobo, LeslieE. Rudolf, Clarence White |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Pathology
medicine.medical_specialty Anastomosis Kidney medicine Humans Transplantation Homologous Acute tubular necrosis Antilymphocyte Serum biology business.industry General Medicine Acute Kidney Injury Kidney Tubular Necrosis Acute medicine.disease Kidney Transplantation Surgery Cold Temperature Transplantation surgical procedures operative Immunoglobulin M biology.protein Tissue Preservation Antibody Cadaveric spasm business Donor kidney |
| Zdroj: | The Lancet. 316:879-882 |
| ISSN: | 0140-6736 |
| DOI: | 10.1016/s0140-6736(80)92046-2 |
| Popis: | Cold-reactive lymphocytotoxins, present in some renal-transplant recipients, may be an important cause of the acute tubular necrosis (ATN) that commonly occurs immediately after transplantation. In a study of transplantation of optimally preserved cadaveric kidneys obtained from heart-beating donors, ATN was found in 10 of 17 recipients with cold antibodies and in only 1 of 21 recipients without such antibodies. Warming of the allograft after completion of anastomosis significantly reduced the incidence of ATN to 18% in recipients with cold antibodies. When pairs of recipients with cold antibodies were transplanted with identically preserved cadaveric kidneys from single donors ATN was observed only in recipients whose donor kidney was not warmed. ATN may result from antibody-mediated damage to vascular endothelial cells during the brief period when the recipient's blood starts flowing into a "cold" allograft. |
| Databáze: | OpenAIRE |
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