Explorative study on the expression of neuregulin-1 gene in peripheral blood of schizophrenia
| Autor: | Jingping Zhao, Wenqiang Li, Zhi-Qing Yuan, Xuan Ouyang, Hongxing Zhang, Lin Xu, Jin-Song Huang, Lu-Xian Lv |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Genetic Markers Male medicine.medical_specialty Pathology Psychosis Adolescent Neuregulin-1 medicine.medical_treatment DNA Mutational Analysis Gene Expression Nerve Tissue Proteins Predictive Value of Tests Internal medicine medicine Humans Genetic Predisposition to Disease Genetic Testing Lymphocytes RNA Messenger Neuregulin 1 Antipsychotic Gene Brain Chemistry Messenger RNA biology General Neuroscience medicine.disease Endocrinology Schizophrenia biology.protein Neuregulin Female Psychology Antipsychotic Agents Diagnosis of schizophrenia |
| Zdroj: | Neuroscience Letters. 438:1-5 |
| ISSN: | 0304-3940 |
| Popis: | Neuregulin-1 (Nrg-1)(1) gene has been considered as a schizophrenia susceptibility gene. In order to observe the association of Nrg-1 gene with schizophrenia, the study was designed to investigate the effect of anti-psychotic treatment on the Nrg-1 mRNA expression in peripheral blood lymphocytes of the patients with a diagnosis of schizophrenia. The Nrg-1 mRNA expression in peripheral blood lymphocytes (PBLs) was measured by using semi-quantitative RT-PCR in 31 first-onset schizophrenia patients, 16 sibling controls and 31 no-sibship controls. Results showed that Nrg-1 mRNA expression in PBLs of patients was lower than that in other two control groups (F=6.722, P=0.002). However, as follow-up time extended, from the second week, Nrg-1 mRNA expression of PBLs in antipsychotic treated patients gradually increased and has obvious statistical significance compared the efficacy of taking anti-psychotic before and after therapy. These results demonstrated that Nrg-1 gene has association with schizophrenia. It is possible to select Nrg-1 mRNA expression of PBLs in schizophrenia patients as a potential therapeutic marker. |
| Databáze: | OpenAIRE |
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