NSES100B protein blood level assessment during a long-distance trail race
| Autor: | Benoit Mauvieux, Jean-Louis Beaudeux, Barbara Alves, Luc Mallet, Charles-Henry Cottart, Romain Jouffroy |
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| Rok vydání: | 2019 |
| Předmět: |
Blood level
Adult Male 030213 general clinical medicine Time Factors Neuropsychological function Physiology Brain damage S100 Calcium Binding Protein beta Subunit Athletic Performance S100B Running 03 medical and health sciences Race (biology) ddc:616.89 0302 clinical medicine NSE medicine Humans S100b protein Brain function Normal range ddc:613 business.industry General Medicine medicine.disease Privation Mountaineering Phosphopyruvate Hydratase En durance exercise Physical Endurance Female medicine.symptom business Reunion Biomarkers Preliminary Data |
| Zdroj: | Annales de biologie clinique, Vol. 77, No 5 (2019) pp. 532-536 |
| ISSN: | 1950-6112 0003-3898 |
| Popis: | The acute and chronic consequences of long-distance running on brain function have received little attention. The impact of such a hard-physical burden associated with sleep privation during such events such has never been explored in terms of neuropsychological function and brain damage. METHODS Blood samples were collected from 4 athletes before, during and at the end of one of two races: Grand Raid de la Reunion 2017 (GRR: 165 km, elevation gain: 9529 m, 2 runners) and Trail de la Bourbon 2017 (TB: 111 km, elevation gain: 6433 m, 2 runners). Serum S100B and NSE levels were measured for each runner before, during and after the race. RESULTS Serum S100B levels (normal range: < 0.15 μg/L) increased early during the race and remained high up to the end of the race in all 4 runners (range: 0.17-0.59 μg/L). NSE level (normal range: < 15 μg/L) increased in 3 of the 4 runners (range: 16.8-39.2 μg/L). CONCLUSIONS This preliminary study shows the potential interest of S100B and NSE serum assessment during long-distance races. Further studies are needed to confirm these results and to investigate the origins and significance of this increase in brain injury markers. |
| Databáze: | OpenAIRE |
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