eNOS gene Glu298Asp variant confer risk in sudden sensorineural hearing loss

Autor:	Neda Jalili, Armita Kakavand Hamidi, Aida Vahidi, Mahsa M. Amoli, Nasrin Yazdani, Nakisa Zarabi Ahrabi, Negin Soroush, Ardavan Tajdini
Rok vydání:	2018
Předmět:	Adult Male Nitric Oxide Synthase Type III Hearing Loss Sensorineural Iran 030204 cardiovascular system & hematology Calcitriol receptor Pathogenesis 03 medical and health sciences 0302 clinical medicine Enos Polymorphism (computer science) Humans Medicine 030223 otorhinolaryngology Genotyping Genetic association Polymorphism Genetic biology business.industry General Medicine Hearing Loss Sudden Middle Aged biology.organism_classification Genotype frequency Otorhinolaryngology Case-Control Studies Immunology Receptors Calcitriol Female Restriction fragment length polymorphism business
Zdroj:	Acta Oto-Laryngologica. 138:904-908
ISSN:	1651-2251 0001-6489
Popis:	Sudden sensorineural hearing loss (SSNHL) causes the loss of hearing of 30 dB or greater on at least three contiguous frequencies. It is known to be a multifactorial disease which the exact cause is unknown, rendering it as an idiopathic disorder of patients.This study aims to shed further light on pathogenesis of this disease by studying the association between eNOS gene Glu298Asp polymorphism and VDR gene FokI polymorphism with SSNHL in Iranian population.This study involves a total of 77 cases and 100 controls, with patients inflicted with SSNHL categorized in case group and healthy subjects as control group. Genotyping of the VDR and eNOS genes was conducted by the polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) method.Our results showed a statistically significant association between genotype frequencies of eNOS gene Glu298Asp polymorphism in case group compared to healthy individuals in the control group (p = .01). Also, TT genotype was significantly the most prevalent genotype in case group in comparison to control group (TT vs GT + GG, OR = 3.5; 95% CI = 1.18-11.79). On the other hand, analysis of VDR gene FokI polymorphism frequencies showed no statistically significant association with SSNHL.Our findings showed a significant association between the eNOS gene Glu298Asp polymorphism and SSNHL in the Iranian population; and "TT" genotype might be considered as a risk factor for SSNHL.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd31a3c0bcfb52ca4de5e7187f76464e https://doi.org/10.1080/00016489.2018.1497806 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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