DABCO promoted one-pot synthesis of dihydropyrano(c)chromene and pyrano[2,3-d]pyrimidine derivatives and their biological activities
| Autor: | Pradeep Paliwal, Shubha Jain, Anjna Bhatewara, G. Neelaiah Babu |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
chemistry.chemical_classification
DABCO Barbituric acid Chemistry(all) Pyrimidine One-pot synthesis General Chemistry Pyrano[2 3-d] pyrimidine Aldehyde chemistry.chemical_compound chemistry Dimedone Multi-component Organic chemistry Knoevenagel condensation Antibacterial activity Dihydropyrano(c)chromene Malononitrile |
| Zdroj: | Journal of Saudi Chemical Society. 18:535-540 |
| ISSN: | 1319-6103 |
| DOI: | 10.1016/j.jscs.2011.10.023 |
| Popis: | A simple and efficient one-pot synthesis of heteroaryl substititued dihydropyrano( c )chromenes and pyrano[2,3- d ]pyrimidines has been developed via initial Knoevenagel, subsequent Micheal and final heterocyclization reactions of heteroaryl aldehyde, malononitrile and barbituric acid/ dimedone. 1,4-Diazabicyclo [2.2.2] octane (DABCO) has been used as a catalyst. Short reaction time, environment friendly procedure and excellent yields are the main advantages of this procedure. All synthesized compounds have shown good antimicrobial activity against different microbial stains. |
| Databáze: | OpenAIRE |
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