[OsIVCl5(Hazole)]− Complexes: Synthesis, Structure, Spectroscopic Properties, and Antiproliferative Activity
| Autor: | Iryna N. Stepanenko, Vladimir B. Arion, Bernhard K. Keppler, Gabriel E. Büchel, Michael A. Jakupec, Michaela Hejl |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Indazoles
Magnetic Resonance Spectroscopy Stereochemistry Electrospray ionization chemistry.chemical_element Crystallography X-Ray Mass spectrometry Medicinal chemistry Inorganic Chemistry Magnetics Cell Line Tumor Electrochemistry Organometallic Compounds Humans Osmium Physical and Theoretical Chemistry Spectroscopy Cell Proliferation Aqueous solution Chemistry Hydrolysis Water Magnetic susceptibility Solubility Pyrazoles Cyclic voltammetry Two-dimensional nuclear magnetic resonance spectroscopy |
| Zdroj: | Inorganic Chemistry. 48:10737-10747 |
| ISSN: | 1520-510X 0020-1669 |
| Popis: | By exploring the Anderson type rearrangement reactions, osmium(IV) complexes of the general formula [cation](+)[Os(IV)Cl(5)(Hazole)](-), where [cation](+) = n-Bu(4)N(+), Hazole = 1H-pyrazole (Hpz) (1), 1H-indazole (Hind) (2), 1H-imidazole (Him) (3), 1H-benzimidazole (Hbzim) (4), 1H,2,4-triazole (Htrz) (5), have been synthesized. To improve water solubility of tetrabutylammonium compounds, complexes with [cation](+) = Na(+) [Hazole = Hpz 6), Hind (7), Htrz (8)] or H(2)azole(+) [Hazole = Hpz (9), Hind (10), Htrz (11)] have been also prepared with the aim of testing them for cytotoxicity in cancer cells. In addition, the preparation of the complex {(n-Bu(4)N)(2)[Os(IV)Cl(6)]}(2)[Os(IV)Cl(4)(Him)(2)] (12) is also reported. The compounds have been comprehensively characterized by elemental analysis, electrospray ionization (ESI) mass spectrometry, spectroscopy (IR, UV-vis, 1D and 2D NMR), cyclic voltammetry, X-ray crystallography (1-6 and 12) and magnetic susceptibility (5). Complexes 6, 7, 9 are kinetically inert in aqueous solution and resistant to hydrolysis. Compounds 6-11 were found to possess modest antiproliferative acitivity in vitro against CH1 (ovarian carcinoma), A549 (non-small cell lung carcinoma), and SW480 (colon adenocarcinoma) cells with IC(50) values in the 10(-4) M concentration range. Replacement of azolium cations by sodium had significant effects; cytotoxicity increased in the case of the pyrazole system from 3 (A549) to the 5.5-fold (CH1). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|