Carotid artery thickness is associated with chronic use of highly active antiretroviral therapy in patients infected with human immunodeficiency virus: A 3.0 Tesla magnetic resonance imaging study

Autor: Rohan Dharmakumar, W. D Hardy, Roya Yumul, Debiao Li, Troy M. LaBounty, Zhaoyang Fan, A Hernandez Conte
Rok vydání: 2015
Předmět:
Male
0301 basic medicine
Cross-sectional study
HIV Infections
Cardiovascular
Gastroenterology
0302 clinical medicine
Antiretroviral Therapy
Highly Active
Carotid artery disease
magnetic resonance imaging
Medicine
Pharmacology (medical)
030212 general & internal medicine
Stroke
Framingham Risk Score
medicine.diagnostic_test
Health Policy
Ultrasound
highly active antiretroviral therapy
Middle Aged
stroke
Magnetic Resonance Imaging
Carotid Arteries
Infectious Diseases
Anti-Retroviral Agents
6.1 Pharmaceuticals
Biomedical Imaging
HIV/AIDS
Infection
Adult
medicine.medical_specialty
Clinical Sciences
Antiretroviral Therapy
carotid artery disease
Article
03 medical and health sciences
Clinical Research
Virology
Diabetes mellitus
Internal medicine
Humans
Highly Active
business.industry
Neurosciences
HIV
Evaluation of treatments and therapeutic interventions
Magnetic resonance imaging
medicine.disease
030112 virology
Confidence interval
Brain Disorders
Surgery
Good Health and Well Being
Cross-Sectional Studies
business
Zdroj: HIV medicine, vol 17, iss 7
ISSN: 1464-2662
DOI: 10.1111/hiv.12351
Popis: Objectives While patients with HIV infection have an elevated stroke risk, ultrasound studies of carotid artery wall thickness have reported variable results. We hypothesized that subjects with HIV infection on chronic highly active antiretroviral therapy (HAART) would have increased carotid artery wall thickness by magnetic resonance imaging (MRI). Methods This cross-sectional study compared carotid artery wall thickness between 26 individuals infected with HIV on chronic HAART and 20 controls, without HIV infection but with similar cardiovascular risk factors, using 3.0-T noncontrast MRI. Inclusion criteria included male gender, age 35–55 years, and chronic HAART (≥ 3 years) among HIV-seropositive subjects; those with known cardiovascular disease or diabetes were excluded. Results Between subjects with HIV infection and controls, there were no differences in mean (±SD) age (47.8 ± 5.0 vs. 47.8 ± 4.7 years, respectively; P = 0.19) or cardiovascular risk factors (P > 0.05 for each). Mean (±SD) wall thickness was increased in those with HIV infection vs. controls for the left (0.88 ± 0.08 vs. 0.83 ± 0.08 mm, respectively; P = 0.03) and right (0.90 ± 0.10 vs. 0.85 ± 0.07 mm, respectively; P = 0.046) common carotid arteries. Among individuals with HIV infection, variables associated with increased mean carotid artery wall thickness included lipoaccumulation [+0.09 mm; 95% confidence interval (CI) 0.03–0.14 mm; P = 0.003], Framingham risk score ≥ 5% (+0.07 mm; 95% CI 0.01–0.12; P = 0.02 mm), and increased duration of protease inhibitor therapy (+0.03 mm per 5 years; 95% CI 0.01–0.06 mm; P = 0.02). Conclusions Individuals with HIV infection on chronic HAART had increased carotid artery wall thickness as compared to similar controls. In subjects with HIV infection, the presence of lipoaccumulation and longer duration of protease inhibitor therapy were associated with greater wall thickness.
Databáze: OpenAIRE
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