Multiple image x-radiography for functional lung imaging
| Autor: | Sheldon Wiebe, Gurpreet Kaur Aulakh, Dean Chapman, A Mann, W M Kuebler, Baljit Singh, George Belev |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Materials science media_common.quotation_subject Radiography Lung injury 030218 nuclear medicine & medical imaging Mice 03 medical and health sciences 0302 clinical medicine X-Ray Diffraction Image Processing Computer-Assisted medicine Animals Contrast (vision) Radiology Nuclear Medicine and imaging Respiratory system Lung media_common Radiological and Ultrasound Technology business.industry Attenuation respiratory system Refraction Molecular Imaging Mice Inbred C57BL 030104 developmental biology medicine.anatomical_structure Contrast ratio business Synchrotrons Biomedical engineering |
| Zdroj: | Physics in Medicine & Biology. 63:015009 |
| ISSN: | 1361-6560 |
| Popis: | Detection and visualization of lung tissue structures is impaired by predominance of air. However, by using synchrotron x-rays, refraction of x-rays at the interface of tissue and air can be utilized to generate contrast which may in turn enable quantification of lung optical properties. We utilized multiple image radiography, a variant of diffraction enhanced imaging, at the Canadian light source to quantify changes in unique x-ray optical properties of lungs, namely attenuation, refraction and ultra small-angle scatter (USAXS or width) contrast ratios as a function of lung orientation in free-breathing or respiratory-gated mice before and after intra-nasal bacterial endotoxin (lipopolysaccharide) instillation. The lung ultra small-angle scatter and attenuation contrast ratios were significantly higher 9 h post lipopolysaccharide instillation compared to saline treatment whereas the refraction contrast decreased in magnitude. In ventilated mice, end-expiratory pressures result in an increase in ultra small-angle scatter contrast ratio when compared to end-inspiratory pressures. There were no detectable changes in lung attenuation or refraction contrast ratio with change in lung pressure alone. In effect, multiple image radiography can be applied towards following optical properties of lung air-tissue barrier over time during pathologies such as acute lung injury. |
| Databáze: | OpenAIRE |
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