Rapid up-regulation of cyclooxygenase-2 by 5-fluorouracil in human solid tumors
| Autor: | Francis G Gabriel, Pauline A. Whitehouse, Augusta Fernando, Pradeep Bhandari, Federica Di Nicolantonio, Simon Toh, Sanjay Sharma, Louise A. Knight, Ian A. Cree, Stuart Mercer, Shaw Somers |
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| Jazyk: | angličtina |
| Rok vydání: | 2005 |
| Předmět: |
Adult
Male Oncology Antimetabolites Antineoplastic Cancer Research medicine.medical_specialty medicine.medical_treatment chemistry.chemical_compound Neoplasms Internal medicine Tumor Cells Cultured Humans Medicine Pharmacology (medical) Doxorubicin Aged Aged 80 and over Pharmacology Cisplatin Chemotherapy business.industry Membrane Proteins Combination chemotherapy Middle Aged Esophageal cancer medicine.disease Up-Regulation Irinotecan Paclitaxel chemistry Cyclooxygenase 2 Prostaglandin-Endoperoxide Synthases Fluorouracil Enzyme Induction Cancer research Female business medicine.drug |
| Popis: | Inhibition of cyclooxygenase (COX)-2 has been associated with reduced growth of malignant cells. Current therapy of gastrointestinal carcinomas involves the use of 5-fluorouracil (5-FU)-based chemotherapy and we have therefore studied the effect of this agent on the expression of COX-2. COX-2 expression was measured by quantitative RT-PCR in biopsies from a series of 14 esophageal carcinomas, six of which had paired samples taken before and after chemotherapy, and in tumor-derived cells exposed to 5-FU in vitro from a series of 44 tumors, including breast, ovarian, esophageal and colonic carcinomas. COX-2 expression was increased by exposure to 5-FU or 5-FU combination chemotherapy in all the tumor types studied, whether measured in biopsies taken before and after 5-FU-based chemotherapy (4-fold increase, p |
| Databáze: | OpenAIRE |
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