Association of genetic variations near P2 promoter of the hepatocyte nuclear factor-4alpha gene and insulin secretion index in Thais
| Autor: | Pongamorn Bunnag, Atana Kongsuksai, Suwannee Chanprasertyothin, Puavilai G, Wallaya Jongjaroenprasert, Boonsong Ongphiphadhanakul |
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| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_specialty
Genotype Endocrinology Diabetes and Metabolism Single-nucleotide polymorphism Type 2 diabetes Biology Polymerase Chain Reaction Polymorphism Single Nucleotide Body Mass Index Endocrinology Asian People Reference Values Internal medicine Diabetes mellitus Insulin Secretion Internal Medicine medicine Humans Insulin Body Weights and Measures Prediabetes Promoter Regions Genetic Genotyping Allele frequency Genetic Variation General Medicine medicine.disease Thailand Hepatocyte nuclear factors Diabetes Mellitus Type 2 Hepatocyte Nuclear Factor 4 Multivariate Analysis |
| Zdroj: | Acta diabetologica. 44(4) |
| ISSN: | 0940-5429 |
| Popis: | This study was aimed to assess the association of the two single nucleotide polymorphisms (SNPs) near P2 promoter (rs1884614 and rs2144908) of hepatocyte nuclear factor-4α (HNF4A) with insulin secretion index and type 2 diabetes in Thais. Participants were categorized into three groups; unrelated type 2 diabetes (N = 219), prediabetes subjects (N = 228), and normal glucose tolerant controls (N = 203). Homeostasis model assessment was calculated for individual insulin secretion and insulin sensitivity index. Genotyping of both SNPs was done by allele-specific PCR technique. Difference of SNP allele frequencies between groups were computed using the χ 2-statistic. Multivariate regression analysis was performed to determine the effect of SNPs on insulin secretion index. The clinical features of all groups were similar. We demonstrated genotype TT at rs1884614, BMI, and waist circumference were significantly associated with insulin secretion index (P = 0.023) but not with diabetes phenotype. |
| Databáze: | OpenAIRE |
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