Clinical profile of patients admitted with hyponatremia in the medical intensive care unit
| Autor: | Siddharth Madnani, Prakash Babaliche, Sajal Kamat |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
030209 endocrinology & metabolism Critical Care and Intensive Care Medicine Urine sodium Sputum culture 03 medical and health sciences 0302 clinical medicine Internal medicine Intensive care medicine 030212 general & internal medicine syndrome of inappropriate antidiuretic hormone secretion Blood urea nitrogen medicine.diagnostic_test business.industry nutritional and metabolic diseases medicine.disease serum sodium tuberculosis Syndrome of inappropriate antidiuretic hormone secretion Urine osmolality Etiology Hyponatremia business moderate and severe hyponatremia Research Article |
| Zdroj: | Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine |
| ISSN: | 1998-359X 0972-5229 |
| DOI: | 10.4103/ijccm.ijccm_257_17 |
| Popis: | Background and Aims: Hyponatremia is the predominant electrolyte abnormality with an incidence rate of approximately 22%. It is the leading cause of morbidity and mortality with scarce data in Indian intensive care settings. The aim of this study is to evaluate the clinical features and etiology of hyponatremia in patients admitted to an Intensive Care Unit (ICU) of a tertiary care hospital. Materials and Methods: A 1-year prospective cross-sectional observational study was conducted, including 100 adult patients with moderate-to-severe hyponatremia admitted to the Medical ICU. Patients underwent investigations such as serum creatinine, blood urea nitrogen, serum osmolality, serum sodium, urine sodium, and urine osmolality, sputum culture, cerebrospinal fluid analysis, and neuroimaging. Data were analyzed using independent sample t-test, Chi-square test, and Fisher's exact test. Results: Vomiting (28) followed by confusion (26) was the most common complaint. Syndrome of inappropriate antidiuretic hormone secretion (SIADH) (46) was the most common etiology for hyponatremia, and euvolemic hypoosmolar hyponatremia (50) was the most common type of hyponatremia. Confusion was significantly high in patients with severe hyponatremia as compared to patients with moderate hyponatremia (22 vs. 4, P < 0.001). In majority of the patients (46), SIADH was the main cause of euvolemic type of hyponatremia (P < 0.001). Increased urine sodium levels were observed in patients with SIADH (46), renal dysfunction (12), and drug-induced etiology (8, P < 0.001). Conclusion: Patients with hyponatremia secondary to an infectious cause should be meticulously screened for tuberculosis. The timely and effective treatment of hyponatremia is determined by the effective understanding of pathophysiology and associated risk factors of hyponatremia. |
| Databáze: | OpenAIRE |
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