Severe delayed haemolytic anaemia associated with artemether-lumefantrine treatment of malaria in a Japanese traveller
| Autor: | Haruhiko Maruyama, Masaharu Kudo, Chihiro Hasegawa, Mikio Kimura |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Microbiology (medical)
Male medicine.medical_specialty Anemia Hemolytic Artemether/lumefantrine Combination therapy 030231 tropical medicine Plasmodium falciparum Administration Oral Artesunate 03 medical and health sciences chemistry.chemical_compound Antimalarials Young Adult 0302 clinical medicine Recurrence Internal medicine parasitic diseases medicine Humans Pharmacology (medical) 030212 general & internal medicine Artemisinin Malaria Falciparum Blackwater fever Fluorenes Lumefantrine biology business.industry biology.organism_classification medicine.disease Haemolysis Artemisinins Infectious Diseases chemistry Ethanolamines Administration Intravenous Drug Therapy Combination Artemether Blackwater Fever business Plasmodium vivax Malaria medicine.drug |
| Zdroj: | Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy. 24(3) |
| ISSN: | 1437-7780 |
| Popis: | Delayed haemolytic anaemia has been reported in association with intravenous artesunate treatment in patients with severe Plasmodium falciparum malaria, and furthermore, oral artemisinin-based combination therapies including artemether-lumefantrine (AL) have also been incriminated. However, definite cases of delayed haemolytic anaemia associated with AL appear to be scarce, as reported cases were often treated concomitantly with other anti-malarials. In this study, we report a severe case of delayed haemolytic anaemia following AL alone in a Japanese traveller with severe parasitaemia caused by numerous P. falciparum parasites and a few P. vivax parasites. We also stress the need by further studies to differentiate between delayed haemolytic anaemia and blackwater fever, the latter being another malaria-related haemolytic condition, more clearly than they are now. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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