Neurointegrity and europhysiology: astrocyte, glutamate, and carbon monoxide interactions
| Autor: | Vicki L Mahan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
gasotransmitters Central Nervous System Central nervous system Citric Acid Cycle Neuroscience (miscellaneous) Glutamic Acid Review Neuroprotection neuroprotection by carbon monoxide carbon monoxide astrocytes glutamate metabolism in the brain astrocyte control of glutamate metabolism neurotherapy neuroprotection GABA lcsh:RD78.3-87.3 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Glutamate-Ammonia Ligase medicine Animals Humans Neurotransmitter Gasotransmitters Neurons Carbon Monoxide Chemistry Catabolism Glutamate receptor Glutathione 030104 developmental biology Anesthesiology and Pain Medicine medicine.anatomical_structure lcsh:Anesthesiology Neuroscience 030217 neurology & neurosurgery Homeostasis Astrocyte |
| Zdroj: | Medical Gas Research, Vol 9, Iss 1, Pp 24-45 (2019) Medical Gas Research |
| ISSN: | 2045-9912 |
| Popis: | Astrocyte contributions to brain function and prevention of neuropathologies are as extensive as that of neurons. Astroglial regulation of glutamate, a primary neurotransmitter, is through uptake, release through vesicular and non-vesicular pathways, and catabolism to intermediates. Homeostasis by astrocytes is considered to be of primary importance in determining normal central nervous system health and central nervous system physiology - glutamate is central to dynamic physiologic changes and central nervous system stability. Gasotransmitters may affect diverse glutamate interactions positively or negatively. The effect of carbon monoxide, an intrinsic central nervous system gasotransmitter, in the complex astrocyte homeostasis of glutamate may offer insights to normal brain development, protection, and its use as a neuromodulator and neurotherapeutic. In this article, we will review the effects of carbon monoxide on astrocyte homeostasis of glutamate. |
| Databáze: | OpenAIRE |
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