A Technique for Accurate Use of CD4+ Cell Counts
| Autor: | K. H. Nott, E. L. C. Ong, C. Bradbeer, Stephen M. Richards, Kav Vedhara, M. H. Snow, E. A. F. Davidson |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
CD4-Positive T-Lymphocytes
Male medicine.medical_specialty Leadership and Management Human immunodeficiency virus (HIV) HIV Infections medicine.disease_cause Cohort Studies symbols.namesake Internal medicine Statistics Humans Medicine Homosexuality Male Cd4 cell count Statistical hypothesis testing business.industry Public Health Environmental and Occupational Health Reproducibility of Results Prognosis Pearson product-moment correlation coefficient CD4 Lymphocyte Count Cohort Disease Progression symbols business Count data |
| Zdroj: | AIDS Patient Care. 9:276-280 |
| ISSN: | 0893-5068 |
| DOI: | 10.1089/apc.1995.9.276 |
| Popis: | Despite uncertainty over their reliability, CD4+ cell counts are used extensively in both clinical and research settings to document progression in HIV infection. We examined, therefore, whether the performance of a simple statistical test would facilitate greater accuracy in the use of this marker. CD4+ cell count data were collected from a cohort of deceased (N = 60) and living HIV-positive gay men (N = 100). Pearson's product moment correlation coefficients were calculated for each individual in order to examine the association between CD4+ counts and time since diagnosis. Correlations of 0.7 or greater were obtained in approximately 50 percent of cases in each cohort. For these individuals, CD4+ cell counts were deemed to be a reliable indicator of rate of progression. The results suggest that the proposed technique ensures greater precision in the use of CD4+ cell counts and that the technique cna be used in individuals with either complete (deceased patients) or partial (living patients) CD4+ data. |
| Databáze: | OpenAIRE |
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