Lifestyle impact on meal-induced insulin sensitization in health and prediabetes: A focus on diet, antioxidants, and exercise interventions
| Autor: | W. Wayne Lautt, Dallas J. Legare, Kawshik K. Chowdhury |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Blood Glucose
medicine.medical_specialty Physiology medicine.medical_treatment Glucose uptake Antioxidants Prediabetic State Eating chemistry.chemical_compound Insulin resistance Physiology (medical) Internal medicine medicine Hyperinsulinemia Animals Humans Prediabetes Exercise Life Style Sensitization Pharmacology Glycogen business.industry Insulin General Medicine Postprandial Period medicine.disease Diet medicine.anatomical_structure Endocrinology Postprandial Liver chemistry Insulin Resistance business |
| Zdroj: | Canadian Journal of Physiology and Pharmacology. 91:91-100 |
| ISSN: | 1205-7541 0008-4212 |
| DOI: | 10.1139/cjpp-2012-0228 |
| Popis: | The augmented whole-body glucose uptake response to insulin during the postprandial state is described as meal-induced insulin sensitization (MIS). MIS occurs when the presence of food in the upper gastrointestinal tract activates 2 feeding signals (activation of hepatic parasympathetic nerves and elevation of hepatic glutathione level), and causes insulin to release hepatic insulin sensitizing substance (HISS), which stimulates glucose uptake in skeletal muscle, heart, and kidneys. HISS action results in nutrient storage, primarily as glycogen. Impairment of HISS release results in the absence of meal-induced insulin sensitization (AMIS), which causes postprandial hyperglycemia and hyperinsulinemia, and chronically leads to the progression to a cluster of metabolic, vascular, and cardiac dysfunctions, which we refer to as components of the AMIS syndrome. Manipulation of the MIS process in health and in disease, by pharmacological and nonpharmacological interventions, is outlined in this review. High fat or sugar supplemented diet reduces MIS; exercise elevates MIS; and antioxidants protect MIS against reductions associated with diet and age. |
| Databáze: | OpenAIRE |
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