First Living Related Kidney Transplantation Results in Excellent Outcomes for Small Children
| Autor: | K Arai, A. Aikawa, K. Sugiyama, Yoshihiro Itabashi, Takeshi Kawamura, Takehiro Ohara, Masaki Muramatsu, Osamu Motoyama, Akira Hasegawa |
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| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_specialty Basiliximab Recombinant Fusion Proteins medicine.medical_treatment Renal function Kidney Chronic allograft nephropathy Living Donors medicine Humans Transplantation Homologous Kidney transplantation Dialysis Antilymphocyte Serum Transplantation business.industry Body Weight Graft Survival Antibodies Monoclonal Infant Immunosuppression Organ Size medicine.disease Kidney Transplantation Survival Analysis Nephrectomy Surgery Treatment Outcome surgical procedures operative Child Preschool Female business Immunosuppressive Agents medicine.drug |
| Zdroj: | Transplantation Proceedings. 37:2947-2950 |
| ISSN: | 0041-1345 |
| DOI: | 10.1016/j.transproceed.2005.06.095 |
| Popis: | Objective. The aim of this study was to evaluated the outcomes of living related kidney transplantation in small children. Materials and methods. Ten pediatric patients with body weights less than 10 kg received parental kidney transplants (five mothers and five fathers). An intra-abdominal approach was used in nine children and a retroperitoneal approach in one child. Bilateral, left, or right nephrectomy was performed in seven, two, and one child, respectively. Immunosuppression consisted of either cyclosporine (n = 7) or tacrolimus (n = 3) with either mizoribine (n = 4) or mycophenolate mofetil (MMF) (n = 5) or azathioprine (n = 1), and methylprednisolone (n = 10). Antilymphocyte globulin was used in the first series of four children; basiliximab in the most recent five children. Results. All renal allografts functioned immediately after transplantation despite the mismatched size of the large renal allografts. Nine of 10 children were alive with a functional allograft at 6 to 196 months posttransplantation. One child died of intra-abdominal bleeding 5 days posttransplantation. One child has suffered chronic allograft nephropathy 11 years posttransplantation (serum creatinine 3.3 mg/dL). The remaining eight children display good renal function (serum creatinine = 0.2 to 1.43 mg/dL). Steroids were withdrawn in eight of nine children; one child continues on alternative-day therapy. One child (LD55) exceeded the mean standard height. The most recent height standard deviation (SD) scores were superior (-1.75 ± 1.39 [-3.83 to 0.54]; P |
| Databáze: | OpenAIRE |
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