Suppression of HIV replication in vitro by CD8+ T-cells from HIV-infected and HIV-seronegative individuals
| Autor: | Detorio Ma, Yamada O, Tesfamariam N, Hossain Mm, Hiroshi Ichimura, Lam-Po-Tang Pr, Takashi Kurimura, Dwyer Jm, Trickett A, Hideaki Tsuchie |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
medicine.medical_treatment
HIV Core Protein p24 HIV Infections Dermatology CD8-Positive T-Lymphocytes Biology Virus Replication Virus Acquired immunodeficiency syndrome (AIDS) HIV Seronegativity medicine Humans Cytotoxic T cell Pharmacology (medical) Sida Cells Cultured Public Health Environmental and Occupational Health virus diseases medicine.disease biology.organism_classification Virology In vitro Infectious Diseases Cytokine Immunology HIV-1 Viral disease CD8 |
| Zdroj: | International Journal of STD & AIDS. 8:307-310 |
| ISSN: | 1758-1052 0956-4624 |
| DOI: | 10.1258/0956462971920145 |
| Popis: | The inhibitory effect of CD8+ T-cells from HIV-infected or HIVseronegative individuals on HIV replication in the naturally-infected CD4+ T-cells in vitro was examined. Not only autologous CD8+ T-cells from HIV-infected individuals but also allogeneic CD8+ T-cells from HIV-seronegative individuals prevented or delayed HIV replication, even in transwell cocultures using a semipermeable 0.45 micron filter. The level of the inhibitory effect of allogeneic CD8+ Tcells from the HIV-seronegative individuals on the HIV replication was varied among CD4+ T-cells obtained from HIV-infected individuals used. The results suggested that CD8+ T-cells from HIV-seronegative individuals as well as HIVinfected individuals could produce some cytokine(s) which suppress HIV replication in vitro . The sensitivity to the cytokine(s) might be variable among HIV strains, depending on differences in the nucleotide sequence of different HIV-1 strains. Further studies of control of HIV replication by CD8+ anti-HIV cytokine(s) should provide new strategies for the therapy of HIV infection. |
| Databáze: | OpenAIRE |
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