Cyclohexanehexol inhibitors of Abeta aggregation prevent and reverse Alzheimer phenotype in a mouse model
| Autor: | Audrey A. Darabie, Amie L. Phinney, Sydney S.N. Wong, Howard T.J. Mount, Jo Anne McLaurin, Peter St George-Hyslop, Michael Brown, Fusheng Chen, Mark H. L. Lambermon, Melissa F. Lan, Paul E. Fraser, Meredith E. Kierstead, Julian E. Cousins, Cheryl A. Hawkes, Janet French, David Westaway |
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| Rok vydání: | 2005 |
| Předmět: |
Gerontology
Genetically modified mouse Mice Transgenic Plaque Amyloid Biology General Biochemistry Genetics and Molecular Biology Pathogenesis chemistry.chemical_compound Amyloid beta-Protein Precursor Mice Alzheimer Disease Memory medicine Animals Nootropic Agents Aβ oligomers General Medicine Synaptic physiology medicine.disease Cyclohexanols Phenotype Amyloid β peptide Disease Models Animal chemistry Synapses Alzheimer's disease Neuroscience scyllo-Inositol |
| Zdroj: | Nature medicine. 12(7) |
| ISSN: | 1078-8956 |
| Popis: | When given orally to a transgenic mouse model of Alzheimer disease, cyclohexanehexol stereoisomers inhibit aggregation of amyloid beta peptide (Abeta) into high-molecular-weight oligomers in the brain and ameliorate several Alzheimer disease-like phenotypes in these mice, including impaired cognition, altered synaptic physiology, cerebral Abeta pathology and accelerated mortality. These therapeutic effects, which occur regardless of whether the compounds are given before or well after the onset of the Alzheimer disease-like phenotype, support the idea that the accumulation of Abeta oligomers has a central role in the pathogenesis of Alzheimer disease. |
| Databáze: | OpenAIRE |
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