Effects of Experimental Hyperprolactinemia and Clomiphene on Pituitary Responsiveness to LHRH and TRH in Men
| Autor: | O. Ylikorkala, L. Rönnberg, M. Reinila |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty Pituitary gland Urology Thyrotropin-releasing hormone Gonadotropin-releasing hormone Peptide hormone Clomiphene Gonadotropin-Releasing Hormone Endocrinology Clomifene Internal medicine medicine Humans Thyrotropin-Releasing Hormone business.industry General Medicine Luteinizing Hormone Middle Aged Prolactin Gonadotropin secretion Hyperprolactinemia medicine.anatomical_structure Pituitary Gland Follicle Stimulating Hormone Sulpiride business hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Andrologia. 17:364-368 |
| ISSN: | 1439-0272 0303-4569 |
| DOI: | 10.1111/j.1439-0272.1985.tb01023.x |
| Popis: | The effect of clomiphene citrate during sulpiride-induced hyperprolactinemia on pituitary function was tested in 8 healthy men, who ingested 100 mg of clomiphene, 150 mg of sulpiride or 100 mg of clomiphene + 150 mg of sulpiride daily for 7 days. Clomiphene treatment increased FSH and LH plasma concentrations and this increase was unaffected by sulpiride-induced hyperprolactinemia. Sulpiride intake alone did not alter serum gonadotropin concentrations. A reduced LH response to LHRH during sulpiride intake was seen, whereas the FSH response was unchanged. The prolactin response to TRH was unaffected during the combined sulpiride + clomiphene ingestion. Sulpiride treatment did not change the basal and/or clomiphene-stimulated gonadotropin secretion in healthy men. Thus, oligozoospermic men using psychotropic drugs and/or with hyperprolactinemia may be suitable candidates for clomiphene treatment. |
| Databáze: | OpenAIRE |
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