Cell Reprogramming in Tumorigenesis and Its Therapeutic Implications for Breast Cancer
| Autor: | Ming-Feng Hou, Ji-Ching Lai, Chang-Shen Lin, Long-Fong Chen, Pei-Yi Chu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Cell
Antineoplastic Agents Breast Neoplasms Review medicine.disease_cause Catalysis Epigenesis Genetic Inorganic Chemistry lcsh:Chemistry Breast cancer breast cancer medicine Animals Humans Cell Lineage Molecular Targeted Therapy Epigenetics Physical and Theoretical Chemistry skin and connective tissue diseases Molecular Biology lcsh:QH301-705.5 Spectroscopy cell plasticity business.industry Stem Cells cell reprogramming Organic Chemistry Transdifferentiation mammary stem cells Cancer Epithelial Cells General Medicine Cellular Reprogramming medicine.disease Computer Science Applications Cell Transformation Neoplastic medicine.anatomical_structure lineage conversion lcsh:Biology (General) lcsh:QD1-999 Cancer research Female Stem cell business Carcinogenesis Reprogramming |
| Zdroj: | International Journal of Molecular Sciences, Vol 20, Iss 8, p 1827 (2019) International Journal of Molecular Sciences |
| ISSN: | 1422-0067 |
| Popis: | Breast cancer is the most common malignancy in women worldwide and can be categorized into several subtypes according to histopathological parameters or genomic signatures. Such heterogeneity of breast cancer can arise from the reactivation of mammary stem cells in situ during tumorigenesis. Moreover, different breast cancer subtypes exhibit varieties of cancer incidence, therapeutic response, and patient prognosis, suggesting that a specific therapeutic protocol is required for each breast cancer subtype. Recent studies using molecular and cellular assays identified a link between specific genetic/epigenetic alterations and distinct cells of origin of breast cancer subtypes. These alterations include oncogenes, tumor suppressor genes, and cell-lineage determinants, which can induce cell reprogramming (dedifferentiation and transdifferentiation) among two lineage-committed mammary epithelial cells, namely basal and luminal cells. The interconversion of cell states through cell reprogramming into the intermediates of mammary stem cells can give rise to heterogeneous breast cancers that complicate effective therapies of breast cancer. A better understanding of mechanisms underlying cell reprogramming in breast cancer can help in not only elucidating tumorigenesis but also developing therapeutics for breast cancer. This review introduces recent findings on cancer gene-mediated cell reprogramming in breast cancer and discusses the therapeutic potential of targeting cell reprogramming. |
| Databáze: | OpenAIRE |
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