The role of 5HT3 in nociceptive processing in the rat spinal cord: results from behavioural and electrophysiological studies
| Autor: | Gang Wu, Alexei Kozlov, S. Barasi, Zahid Ali |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Male
Indoles Time Factors Microinjections Tropisetron Biguanides Stimulation medicine Noxious stimulus Animals Rats Wistar Receptor Microinjection 5-HT receptor Pain Measurement business.industry General Neuroscience Spinal cord Ondansetron Rats Serotonin Receptor Agonists Electrophysiology medicine.anatomical_structure Nociception Spinal Cord Receptors Serotonin Serotonin Antagonists business Neuroscience |
| Zdroj: | Neuroscience letters. 208(3) |
| ISSN: | 0304-3940 |
| Popis: | Recent studies have suggested that activity at different 5HT receptor subtypes in the spinal cord either inhibits or facilitates nociceptive processing in the spinal cord. The present study has examined the role of 5HT 3 receptors in nociceptive processing in the dorsal horn of the rat spinal cord. Using both behavioural and electrophysiological studies, 5HT 3 ligands have been applied by a common route (i.e. intrathecal microinjection). In addition, only noxious heat has been used as a form of stimulation. Intrathecal injection of mCPBG (0.02–0.2 nmol) increased the responsiveness of dorsal horn neurones to noxious stimulation. In contrast, two 5HT 3 antagonists (ICS 205–930 (0.015–0.15 nmol) and GR 380032F (ondansetron 34 nmol)) reduced nociceptive responses. Using doses which influenced nociceptive neuronal responses no significant change in TFL was recorded. These findings suggest that activation at 5HT 3 receptor facilitates nociceptive responses of some dorsal horn neurones; these results are discussed in relation to earlier reports concerning alternative effects. |
| Databáze: | OpenAIRE |
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