Diversity of cultivable fungal endophytes in Paullinia cupana (Mart.) Ducke and bioactivity of their secondary metabolites

Autor: Elisabeth Aparecida Furtado de Mendonça, Érica de Melo Reis, Olívia Moreira Sampaio, Ana Paula de Araújo Boleti, Marcos Antônio Soares, Marilene Borges Silva Passos, Ana Helena Januário, Edson Lucas dos Santos, Rhavena Graziela Liotti, Carmen Lucia Bassi Branco, Gilvan Ferreira da Silva, Fábio de Azevedo Silva
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
Fungal Structure
Secondary Metabolism
lcsh:Medicine
Plant Science
Diaporthe phaseolorum
medicine.disease_cause
Pathology and Laboratory Medicine
Plant Roots
Medicine and Health Sciences
Endophytes
Paullinia
Cluster Analysis
lcsh:Science
Pathogen
Fungal Pathogens
Multidisciplinary
Geography
Ecology
Antimicrobials
Plant Anatomy
Eukaryota
Drugs
Biodiversity
Phylogeography
Biogeography
Community Ecology
Medical Microbiology
Seeds
Metabolome
Pathogens
Research Article
Ecological Metrics
Mycology
CHO Cells
Biology
Microbiology
03 medical and health sciences
food
Cricetulus
Quantitative Trait
Heritable
Microbial Control
Botany
medicine
Genetics
Paullinia cupana
Animals
Metabolomics
Microbiome
Secondary metabolism
Microbial Pathogens
Community Structure
Pharmacology
Evolutionary Biology
Population Biology
Pseudomonas aeruginosa
Host (biology)
Ecology and Environmental Sciences
lcsh:R
Organisms
Fungi
Species diversity
Biology and Life Sciences
Species Diversity
biology.organism_classification
food.food
030104 developmental biology
Earth Sciences
Antibacterials
lcsh:Q
Population Genetics
Zdroj: PLoS ONE, Vol 13, Iss 4, p e0195874 (2018)
PLoS ONE
ISSN: 1932-6203
Popis: Paullinia cupana is associated with a diverse community of pathogenic and endophytic microorganisms. We isolated and identified endophytic fungal communities from the roots and seeds of P. cupana genotypes susceptible and tolerant to anthracnose that grow in two sites of the Brazilian Amazonia forest. We assessed the antibacterial, antitumor and genotoxic activity in vitro of compounds isolated from the strains Trichoderma asperellum (1BDA) and Diaporthe phaseolorum (8S). In concert, we identified eight fungal species not previously reported as endophytes; some fungal species capable of inhibiting pathogen growth; and the production of antibiotics and compounds with bacteriostatic activity against Pseudomonas aeruginosa in both susceptible and multiresistant host strains. The plant genotype, geographic location and specially the organ influenced the composition of P. cupana endophytic fungal community. Together, our findings identify important functional roles of endophytic species found within the microbiome of P. cupana. This hypothesis requires experimental validation to propose management of this microbiome with the objective of promoting plant growth and protection.
Databáze: OpenAIRE
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