Hemodynamic changes in the posterior cerebral circulation triggered by insufficient sympathetic innervation--cause of primary intracerebral hemorrhage?
| Autor: | Siniša Dunatov, Marina Bralic, Igor Antončić |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Cerebellum
Sympathetic Nervous System Primary intracerebral hemorrhage sympathetic innervation Biophysics Hemodynamics Blood Pressure Models Biological Cerebral circulation BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences. Neurology sympathetic innervation medicine Edema Humans Primary intracerebral hemorrhage Autoregulation Cerebral perfusion pressure Cerebral Hemorrhage Intracerebral hemorrhage business.industry Microcirculation Brain BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti. Neurologija General Medicine Models Theoretical medicine.disease Kinetics Blood pressure medicine.anatomical_structure Cerebral blood flow Anesthesia Cerebrovascular Circulation Hypertension business |
| Zdroj: | Medical Hypotheses Volume 76 Issue 5 |
| ISSN: | 0306-9877 |
| DOI: | 10.1016/j.mehy.2011.01.027 |
| Popis: | Primary intracerebral hemorrhage (ICH) is caused by hypertensive disease of small penetrating blood vessels in the basal ganglia, brain stem and cerebellum. Those regions are supplied by arteries of the so-called posterior brain circulation with insufficient sympathetic innervation. We propose the following hypothesis: due to insufficient sympathetic innervation hemodynamic changes occur in the vascular bed of the posterior brain circulation serving as a key factor for arterial rupture. If autoregulation is insufficient to maintain normal cerebral blood flow, in abrupt rise in the blood pressure, the amount of blood is rising causing higher static pressure, and according to Laplace’s law higher pressure and larger radius leads to higher wall tension and subsequent rupture of arterial wall previously weakened by prolonged hypertension. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect