Investigation of Thiol/Disulfide Homeostasis and Ischemia-Modified Albumin Levels in Children with Wilson Disease
| Autor: | Ferit Durankuş, Sebahat Cam, Ozcan Erel, Yakup Albayrak, Yavuz Tokgöz, Ömer Faruk Beşer, Eda Sünnetçi, Cemil Nural, Ömer Akarsu, Ramazan Durankuş |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Serum Albumin Human 030105 genetics & heredity medicine.disease_cause Thiol disulfide homeostasis Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Hepatolenticular Degeneration Internal medicine medicine Homeostasis Humans Disulfides Sulfhydryl Compounds Child Serum Albumin chemistry.chemical_classification 030219 obstetrics & reproductive medicine business.industry Mean value Ischemia-modified albumin Disulfide bond Albumin General Medicine Oxidative Stress Endocrinology chemistry Pediatrics Perinatology and Child Health Thiol business Oxidative stress Biomarkers |
| Zdroj: | Fetal and pediatric pathology. 41(4) |
| ISSN: | 1551-3823 |
| Popis: | BACKGROUND The aim of the present study was to assess thiol/disulfide homeostasis (TDH) parameters and ischemia-modified albumin (IMA) levels in children with Wilson Disease (WD) and to compare them to healthy controls. Methods: Based on the inclusion and exclusion criteria, fifteen children with WD and twenty-nine healthy children were enrolled, and serum thiol/disulfide and IMA levels were compared between groups. Results: The mean values of native and total thiols were significantly lower in the WD group than in the control group. The mean value of disulfide was significantly higher in the WD group than in the control group. The mean percentages of disulfide/total thiol and native thiol/total thiol were higher in the WD group than in the control group. The IMA value was also higher in the WD group than in the control group. Conclusion: The present study demonstrating altered thiol/disulfide parameters indicates increased oxidative stress in children with WD. |
| Databáze: | OpenAIRE |
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