Noninvasive Microsurgery Using Aptamer-Functionalized Magnetic Microdisks for Tumor Cell Eradication
| Autor: | Anna S. Zamay, Sergey S. Zamay, P. D. Kim, Maxim V. Berezovski, Viktor Y. Prinz, V. S. Prokopenko, Yury E. Glazyrin, V. A. Seleznev, Ana Gargaun, Tatiana I. Ivanchenko, Irina V. Garanzha, Valery V. Denisenko, Valentina L. Grigorieva, Tatiana N. Zamay, I. V. Belyanina, Dmitry V. Veprintsev, Alexey E. Sokolov, Galina S. Zamay, Alexandr V. Shabanov, Olga S. Kolovskaya |
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| Rok vydání: | 2017 |
| Předmět: |
Male
Microsurgery Programmed cell death Materials science Filamins Magnetic Field Therapy Aptamer 02 engineering and technology Injections Intralesional 010402 general chemistry 01 natural sciences Biochemistry Cell membrane Mice In vivo Drug Discovery Genetics medicine Animals Sulfhydryl Compounds Carcinoma Ehrlich Tumor Molecular Biology Mice Inbred ICR Aptamers Nucleotide equipment and supplies 021001 nanoscience & nanotechnology Fibronectins 0104 chemical sciences Magnetic Fields medicine.anatomical_structure Apoptosis Cancer cell Magnets Cell disruption Biophysics Molecular Medicine 0210 nano-technology Neoplasm Transplantation Protein Binding |
| Zdroj: | Nucleic Acid Therapeutics. 27:105-114 |
| ISSN: | 2159-3345 2159-3337 |
| Popis: | Magnetomechanical cell disruption using nano- and microsized structures is a promising biomedical technology used for noninvasive elimination of diseased cells. It applies alternating magnetic field (AMF) for ferromagnetic microdisks making them oscillate and causing cell membrane disruption with cell death followed by apoptosis. In this study, we functionalized the magnetic microdisks with cell-binding DNA aptamers and guided the microdisks to recognize cancerous cells in a mouse tumor in vivo. Only 10 min of the treatment with a 100 Hz AMF was enough to eliminate cancer cells from a malignant tumor. Our results demonstrate a good perspective of using aptamer-modified magnetic microdisks for noninvasive microsurgery for tumors. |
| Databáze: | OpenAIRE |
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