Effect of repetitive transcranial magnetic stimulation on the cognitive impairment induced by sleep deprivation: a randomized trial
| Autor: | Hailong Lyu, Manli Huang, Hetong Zhou, Yueran Yu, Shaohua Hu, Xu Yi, Jianbo Hu, Tingting Mou, Shangda Li, Gongde Shi |
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| Rok vydání: | 2020 |
| Předmět: |
Elementary cognitive task
Hypothalamo-Hypophyseal System medicine.medical_treatment Pituitary-Adrenal System Prefrontal Cortex Stimulation behavioral disciplines and activities law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law medicine Humans Cognitive Dysfunction business.industry Cognition General Medicine Transcranial Magnetic Stimulation Transcranial magnetic stimulation Sleep deprivation Mood 030228 respiratory system Anesthesia Anxiety Sleep Deprivation medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Sleep medicine. 77 |
| ISSN: | 1878-5506 |
| Popis: | Objective Currently, an efficient method for improving cognitive impairment due to sleep deprivation (SD) is lacking. The aim of this study is to evaluate the effect of high-frequency repetitive transcranial magnetic stimulation (rTMS) during SD on reversing the adverse effects of SD. Methods A total of 66 healthy people were randomized into the rTMS group and sham group. Both groups were deprived of sleep for 24 h. During SD, participants were asked to complete several cognitive tasks and underwent mood assessments. Saliva cortisol levels, plasma concentrations of brain-derived neurotrophic factor (BDNF), precursor BDNF (proBDNF), and tissue-type plasminogen activator (tPA), and frontal blood activation were detected before and after SD. The rTMS group received real rTMS stimulation for 2 sessions of 10 Hz rTMS (40 trains of 50 pulses with a 20-second intertrain interval) to the left dorsolateral prefrontal cortex and the sham group received sham stimulation during SD. Results Twenty-four hours of SD induced a reduced accuracy in the n-back task, increases in both anxiety and depression, increased cortisol levels, decreased frontal blood activation and decreased BDNF levels in healthy people. Notably, rTMS improved the hyperactivity of the hypothalamic-pituitary-adrenal axis and decreased frontal blood activation induced by SD, and reduced the consumption of plasma proBDNF. Conclusions Twenty-four hours of SD induced a cognitive impairment. The administration of high-frequency rTMS during sleep deprivation exerted positive effects on HPA axis and frontal activation and might help alleviate cognitive impairment in the long term. |
| Databáze: | OpenAIRE |
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