The leaky lung test: a pilot study using inhaled mannitol to measure airway barrier function in asthma

Autor: Timothy Smyth, Nicole Ransom, Sophia Eliseeva, Janelle Veazey, Kim Le, Jon Meddings, Sara E. Hillman, Steve N. Georas
Rok vydání: 2018
Předmět:
Pulmonary and Respiratory Medicine
Male
Time Factors
Pilot Projects
Severity of Illness Index
Bronchial Provocation Tests
Drug Administration Schedule
Epithelium
Statistics
Nonparametric
Article
03 medical and health sciences
0302 clinical medicine
Reference Values
Forced Expiratory Volume
Administration
Inhalation
medicine
Immunology and Allergy
Humans
Mannitol
030212 general & internal medicine
Anti-Asthmatic Agents
Airway Management
Lung
Barrier function
Asthma
Epithelial barrier
Analysis of Variance
Dose-Response Relationship
Drug
business.industry
Airway inflammation
respiratory system
medicine.disease
respiratory tract diseases
medicine.anatomical_structure
030228 respiratory system
Area Under Curve
Case-Control Studies
Pediatrics
Perinatology and Child Health
Immunology
Airway Remodeling
Female
business
Airway
medicine.drug
Zdroj: J Asthma
ISSN: 1532-4303
Popis: OBJECTIVE: Airway epithelial barrier dysfunction is emerging as an important feature of asthma pathogenesis, but this is difficult to measure in individual subjects. We aimed to develop a non-invasive way to measure airway permeability in asthma. METHODS: Healthy controls and subjects with mild asthma inhaled dry powder mannitol in a dose-escalating manner on two separate occasions, stopping at 155 mg or 315 mg. Serum mannitol levels were measured at baseline and then 30, 90, and 150 minutes after mannitol inhalation. Mannitol absorption was compared with measurements of airflow obstruction (FEV1) and airway inflammation (FeNO). RESULTS: Serum mannitol levels increased in a time- and dose-dependent manner in both healthy control and subjects with asthma. There were no significant differences in mannitol absorption when comparing healthy controls and subjects with asthma. Mannitol absorption did not correlate with markers of airway obstruction or inflammation. CONCLUSIONS: Measuring serum concentrations of mannitol after inhalation challenge can potentially provide insights into airway barrier function in asthma.
Databáze: OpenAIRE
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