Synthesis of Chitosan Microspheres Containing Pendant Cyclodextrin Moieties and their Interaction with Biological Active Molecules
| Autor: | About-Jaudet Elie, Muller Guy, Picton Luc, LeCerf Didier, Mocanu Georgeta, Carpov Adrian |
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| Přispěvatelé: | 'Petru Poni' Institute of Macromolecular Chemistry, Polymères, biopolymères, membranes (PBM), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU) |
| Jazyk: | angličtina |
| Rok vydání: | 2004 |
| Předmět: |
Pharmaceutical Science
Ionic bonding macromolecular substances 010402 general chemistry Piroxicam 01 natural sciences Suspension (chemistry) Nitrophenols Chitosan Nalidixic Acid chemistry.chemical_compound medicine polycyclic compounds Combinatorial Chemistry Techniques Molecule Organic chemistry [CHIM]Chemical Sciences Drug Interactions chemistry.chemical_classification Cyclodextrins Cyclodextrin 010405 organic chemistry Chemistry technology industry and agriculture 0104 chemical sciences Molecular Weight carbohydrates (lipids) microspheres [CHIM.POLY]Chemical Sciences/Polymers cyclodextrin lipids (amino acids peptides and proteins) Glutaraldehyde controlled release Conjugate medicine.drug |
| Zdroj: | Current Drug Delivery Current Drug Delivery, Bentham Science Publishers, 2004, 1 (3), pp.227-233. ⟨10.2174/1567201043334777⟩ |
| ISSN: | 1567-2018 |
| DOI: | 10.2174/1567201043334777⟩ |
| Popis: | International audience; A new route to obtain chitosan derivatives containing cyclodextrin moieties as pendant groups was developed. The chitosan microspheres, obtained through crosslinking with glutaraldehyde of an acetic acid solution of chitosan, in an organic suspension medium, were reacted with chloroacyl cyclodextrins in organic basic solvents. The acyl cyclodextrin moieties are linked to the chitosan microspheres through C-N bonds, with the elimination of HCl; higher amounts of acyl cyclodextrin are linked to the microspheres with a smaller crosslinking degree. The chitosan-cyclodextrin conjugates retain higher amounts of bioactive substances (nalidixic acid, piroxicam) or of p-nitrophenol (model substance) than their parent chitosan supports, both by ionic forces and by the formation of inclusion complexes in the cyclodextrin inner cavities. After these preliminary studies, one can appreciate that the cyclodextrin-chitosan conjugates could be used as supports for chromatographic separations or controlled release drug systems. |
| Databáze: | OpenAIRE |
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