Uncertainty following an inconclusive result from the BRCA1/2 genetic test: A review about psychological outcomes
| Autor: | Sonia Monique Bramanti, Carmen Trumello, Alessandra Cavallo, Ivana Antonucci, Lucia Lombardi, Alessandra Babore, Liborio Stuppia |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Genetic testing
Systematic Reviews endocrine system diseases Psychological distress Review Inconclusive result Anxiety 03 medical and health sciences Brca1 2 mutation 0302 clinical medicine medicine skin and connective tissue diseases Depression (differential diagnoses) medicine.diagnostic_test Depression business.industry BRCA1/2 mutation 030227 psychiatry Test (assessment) medicine.symptom business 030217 neurology & neurosurgery Clinical psychology |
| Zdroj: | World Journal of Psychiatry |
| ISSN: | 2220-3206 |
| DOI: | 10.5498/wjp.v11.i5.189 |
| Popis: | BACKGROUND An inconclusive result from BRCA1/2 genetic testing indicates that a genetic variant of uncertain significance is detected. This case constitutes the majority of genetic test results, but studies specifically addressing the psychological adjustment of people with inconclusive results are scarce. AIM To examine psychological outcomes of receiving an uninformative BRCA1/2 test result. METHODS PubMed, PsychInfo, and Cochrane Central Register of Controlled Trials were screened for studies focusing on distress, anxiety, and depression levels in individuals with inconclusive genetic test results. This review is based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses method. RESULTS Studies on psychological outcomes of inconclusive BRCA1/2 focused on general and specific distress, anxiety, and depression. Overall, they produced mixed results. These inconsistent findings are probably due to the uncertainty caused by this type of result, that may also influence the decisions of individuals about surveillance and prophylactic options, reducing their compliance. In addition, this review highlights specific risk and protective factors that affect psychological adjustment in individuals with an inconclusive genetic testing result. CONCLUSION Individuals with inconclusive genetic test results need specific educational programs and support to better understand the meaning of their results in order to be able to make decisions about surveillance and prophylactic options. |
| Databáze: | OpenAIRE |
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