Short-term oestrogen replacement therapy improves insulin resistance, lipids and fibrinolysis in postmenopausal women with NIDDM
| Autor: | C. Kluft, H.M.J. Krans, H.E. Brussaard, Marijke Frölich, J. A. Gevers Leuven |
|---|---|
| Přispěvatelé: | Gaubius Instituut TNO |
| Jazyk: | angličtina |
| Rok vydání: | 1997 |
| Předmět: |
Glucogenesis
endocrine system diseases Endocrinology Diabetes and Metabolism medicine.medical_treatment Low density lipoprotein cholesterol Plasminogen activator Fatty Acids Nonesterified chemistry.chemical_compound Insulin Apolipoprotein a1 Lipoprotein profiles Apolipoprotein b High density lipoprotein cholesterol C-Peptide Estradiol C-peptide Hepatic glucose production Fibrinolysis Estrogen Replacement Therapy Coagulation factors Middle Aged Insulin sensitivity Cardiovascular disease Blood clotting factor Lipids Postmenopause Cholesterol Plasminogen activator inhibitor-1 Tissue Plasminogen Activator Female Adult medicine.medical_specialty Clinical article Lipoproteins Biology Insulin resistance Double-Blind Method Diabetes mellitus Internal medicine Plasminogen Activator Inhibitor 1 Internal Medicine medicine Humans Triglycerides Aged Glycated Hemoglobin Hemoglobin A Glycosylated nutritional and metabolic diseases Glycosylated hemoglobin medicine.disease Cardiovascular risk Oestrogen therapy Estrogen therapy Endocrinology chemistry Diabetes Mellitus Type 2 Glucose regulation Non-insulin-dependent diabetes mellitus Non insulin dependent diabetes mellitus Insulin Resistance |
| Zdroj: | Diabetologia, 7, 40, 843-849 |
| Popis: | Oestrogen replacement therapy is associated with a decreased risk of cardiovascular disease in postmenopausal women. Patients with non-insulin- dependent diabetes mellitus (NIDDM) have an increased cardiovascular risk. However, oestrogen replacement therapy is only reluctantly prescribed for patients with NIDDM. In a double blind randomized placebo controlled trial we assessed the effect of oral 17 β-estradiol during 6 weeks in 40 postmenopausal women with NIDDM. Glycated haemoglobin (HbA(1c)), insulin sensitivity, suppressibility of hepatic glucose production, lipoprotein profile and parameters of fibrinolysis were determined. The oestrogen treated group demonstrated a significant decrease of HbA(1c) and in the normotriglyceridaemic group a significantly increased suppression of hepatic glucose production by insulin. Whole body glucose uptake and concentrations of non-esterified fatty acids did not change. LDL-cholesterol- and apolipoprotein B levels decreased, and HDL-cholesterol, its subfraction HDL2-cholesterol and apolipotrotein A1 increased. The plasma triglyceride level remained similar in both groups. Both the concentration of plasminogen activator inhibitor-1 antigen and its active subfraction decreased. Tissue type plasminogen activator activity increased significantly only in the normotriglyceridaemic group. Oestrogen replacement therapy improves insulin sensitivity in liver, glycaemic control, lipoprotein profile and fibrinolysis in postmenopausal women with NIDDM. For a definite answer as to whether oestrogens can be more liberally used in NIDDM patients, long term studies including the effect of progestogens are necessary. |
| Databáze: | OpenAIRE |
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