Sufficient vitamin D status positively modified ventilatory function in asthmatic children following a Mediterranean diet enriched with fatty fish intervention study
| Autor: | Charis Katsardis, Maria Michelle Papamichael, Bircan Erbas, Katrina A Lambert, Dimitris Tsoukalas, Catherine Itsiopoulos |
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| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Spirometry Mediterranean diet Endocrinology Diabetes and Metabolism Physiology 030209 endocrinology & metabolism Diet Mediterranean Pulmonary function testing 03 medical and health sciences FEV1/FVC ratio 0302 clinical medicine Endocrinology Vitamin D and neurology Animals Humans Medicine Vitamin D Child Lung Asthma Meal 030109 nutrition & dietetics Nutrition and Dietetics medicine.diagnostic_test business.industry Fishes Vitamins medicine.disease Respiratory Function Tests Seafood Child Preschool Exhaled nitric oxide Respiratory Physiological Phenomena Female business |
| Zdroj: | Nutrition Research. 82:99-109 |
| ISSN: | 0271-5317 |
| DOI: | 10.1016/j.nutres.2020.08.004 |
| Popis: | Asthma in children is the most prevalent allergic disease worldwide that has become a major public health priority. The objective of this study was to examine the relationship between baseline serum vitamin D status, spirometry, and fractional exhaled nitric oxide levels (FeNO) in 64 Greek children with 'mild asthma' aged 5 to 12 years (51.6% male) in a dietary intervention study. We hypothesized that baseline serum vitamin D levels modify the beneficial response of fatty fish intake on pulmonary function in asthmatic children following a Mediterranean diet. The intervention group consumed 2 fatty fish meals/week (≥150 g cooked filleted fish/meal) as part of the Mediterranean diet for six months, and the control group consumed their usual diet. Baseline serum 25(OH)D was determined using enzyme-linked immunoassay and defined as sufficient levels of 25(OH)D ≥25 ng/mL. Only 36% of children were graded as sufficient in 25(OH)D levels on entry into the study with a higher proportion of girls insufficient than boys (61% vs 39% respectively). Participants with sufficient levels of serum 25(OH)D at baseline, consuming the intervention diet increased FEV1/FVC by 4.89 units (β = 4.89; 95%CI: 1.19-8.61; p = 0.013) and FEF25-75% by 12.83 units (β = 12.83; 95%CI: 4.27-21.40; p = 0.006) compared to controls. No significant differences in pulmonary function or FeNO were observed for those with insufficient levels of 25(OH) D in the intervention or control groups. In conclusion, sufficient serum vitamin D levels enhanced ventilatory function in response to a dietary intervention in asthmatic children. |
| Databáze: | OpenAIRE |
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