Resting-State Networks as Simultaneously Measured with Functional MRI and PET
| Autor: | Igor Yakushev, Christian Sorg, Timo Grimmer, Valentin Riedl, Andrei Manoliu, Alexandre Savio, Vince D. Calhoun, Alexander Drzezga, Srinivas Rachakonda, Sarah Fünger, Masoud Tahmasian |
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| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
medicine.diagnostic_test Resting state fMRI Nerve net business.industry Neural substrate Magnetic resonance imaging Brain mapping 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Neurology Positron emission tomography medicine Radiology Nuclear Medicine and imaging Radiology business Neuroscience 030217 neurology & neurosurgery Preclinical imaging Default mode network |
| Zdroj: | Journal of Nuclear Medicine. 58:1314-1317 |
| ISSN: | 2159-662X 0161-5505 |
| Popis: | Functional MRI (fMRI) studies reported disruption of resting-state networks (RSNs) in several neuropsychiatric disorders. PET with (18)F-FDG captures neuronal activity that is in steady state at a longer time span and is less dependent on neurovascular coupling. Methods: In the present study, we aimed to identify RSNs in (18)F-FDG PET data and compare their spatial pattern with those obtained from simultaneously acquired resting-state fMRI data in 22 middle-aged healthy subjects. Results: Thirteen and 17 meaningful RSNs could be identified in PET and fMRI data, respectively. Spatial overlap was fair to moderate for the default mode, left central executive, primary and secondary visual, sensorimotor, cerebellar, and auditory networks. Despite recording different aspects of neural activity, similar RSNs were detected by both imaging modalities. Conclusion: The results argue for the common neural substrate of RSNs and encourage testing of the clinical utility of resting-state connectivity in PET data. |
| Databáze: | OpenAIRE |
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