Increased Virulence of a Human Enterovirus (Coxsackievirus B3) in SeleniumDeficient Mice
| Autor: | Orville A. Levander, Virginia C. Morris, Melinda A. Beck, Qing Shi, Lisa H. Rohr, Peter C. Kolbeck |
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| Rok vydání: | 1994 |
| Předmět: |
Male
Myocarditis viruses Population Coxsackievirus Infections Virulence Lymphocyte proliferation Lymphocyte Activation medicine.disease_cause Virus Microbiology Mice Selenium Serial passage medicine Animals Immunology and Allergy Serial Passage Neutralizing antibody education Glutathione Peroxidase education.field_of_study biology Myocardium virus diseases Heart medicine.disease Virology Enterovirus B Human Killer Cells Natural Infectious Diseases Liver biology.protein Enterovirus |
| Zdroj: | Journal of Infectious Diseases. 170:351-357 |
| ISSN: | 1537-6613 0022-1899 |
| Popis: | Coxsackievirus B3 (CVB3/20)-induced myocarditic lesions occurred more quickly and were more severe and virus titers in heart and liver were higher in selenium (Se)-deficient than Se-adequate mice. NK cell activity and serum neutralizing antibody titers were similar in both Se-adequate and -deficient CVB3/20-infected mice; however, lymphocyte proliferation to both mitogen and antigen was decreased in Se-deficient mice. CVB3/20 isolated from Se-deficient donor mice and inoculated into Se-adequate recipient mice induced severe myocarditis. In contrast, CVB3/20 isolated from Se-adequate donor mice and inoculated into Se-adequate recipient mice induced only moderate myocarditis, similar to that caused by the original virus stock. Thus, the general population of CVB3/20 virions, as a consequence of replicating in an Se-deficient host, underwent a phenotypic change to increased virulence. These results have important implications for the emergence of virulent viruses. |
| Databáze: | OpenAIRE |
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