Inhibitors of α-Synuclein Fibrillation and Oligomer Toxicity in Rosa damascena: The All-Pervading Powers of Flavonoids and Phenolic Glycosides
| Autor: | Gunna Christiansen, Daniel E. Otzen, Jane L. Ward, Duncan S. Sutherland, Hossein Mohammad-Beigi, Hoda Eskandari, Clarice Noleto-Dias, Ahmed F. Tawfike, Mustafa Ghanadian, Charlotte Lomax |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Amyloid
Alpha-Synuclein Physiology Cognitive Neuroscience Rosa damascena Biochemistry Rosa × damascena 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Oligomerization Gallic acid Neurodegeneration 030304 developmental biology α-Synuclein Fibrillation chemistry.chemical_classification 0303 health sciences Traditional medicine biology Glycoside Plant Cell Biology General Medicine biology.organism_classification Cell toxicity chemistry Polyphenol Toxicity Parkinson’s disease Phenolics medicine.symptom Sugars Quercetin Kaempferol 030217 neurology & neurosurgery |
| Zdroj: | Eskandari, H, Ghanadian, M, Noleto-Dias, C, Lomax, C, Tawfike, A, Christiansen, G, Sutherland, D S, Ward, J L, Mohammad-Beigi, H & Otzen, D E 2020, ' Inhibitors of α-Synuclein fibrillation and oligomer toxicity in Rosa damascena : the all-pervading powers of flavonoids and phenolic glycosides ', ACS Chemical Neuroscience, vol. 11, no. 19, pp. 3161–3173 . https://doi.org/10.1021/acschemneuro.0c00528 |
| ISSN: | 1948-7193 |
| DOI: | 10.1021/acschemneuro.0c00528 |
| Popis: | There is an intense search for natural compounds that can inhibit the oligomerization and fibrillation of α-Synuclein (α-Syn), whose aggregation is key to the development of Parkinson's disease (PD). Rosa damascena is a medicinal herb widely used in Middle Eastern food, ceremonies, and perfumes. The herb is known to contain many different polyphenols. Here we investigated the existence of α-Syn fibrillation inhibitors in R. damascena extract. Different HPLC fractions of the extract were assessed in α-Syn fibrillation and toxicity assays. The most active fractions led to the formation of more α-Syn oligomers but with less toxicity to SH-SY5Y cells, according to MTT and LDH assays. LC-MS analysis identified gallic acid, kaempferol 3-glucoside, kaempferol-3-O-β-rutinoside, and quercetin which were subsequently shown to be strong α-Syn fibrillation inhibitors. Our results highlight the benefits of R. damascena extract to combat PD at the population level. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|