Oral Administration of Compound Probiotics Ameliorates HFD-Induced Gut Microbe Dysbiosis and Chronic Metabolic Inflammation via the G Protein-Coupled Receptor 43 in Non-alcoholic Fatty Liver Disease Rats
| Autor: | Yanning Chen, Chenli Lin, Yupei Zhang, Qinhe Yang, Yifang He, Yin-Ji Liang, Chan Liu, Shu Liang, Yuanjun Deng |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty 030106 microbiology Population Administration Oral Fatty Acids Nonesterified Gut flora Diet High-Fat Microbiology Receptors G-Protein-Coupled Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound Non-alcoholic Fatty Liver Disease Oral administration Internal medicine medicine Animals education Molecular Biology Inflammation chemistry.chemical_classification education.field_of_study biology Cholesterol Probiotics Ruminococcus Fatty liver Fatty acid Fatty Acids Volatile medicine.disease biology.organism_classification Lipids Gastrointestinal Microbiome Rats 030104 developmental biology Endocrinology chemistry Chronic Disease Body Composition Cytokines Dysbiosis Molecular Medicine |
| Zdroj: | Probiotics and Antimicrobial Proteins. 11:175-185 |
| ISSN: | 1867-1314 1867-1306 |
| Popis: | The aim of this study was to investigate how the effects of compound probiotics modulate the gut microbiota, short-chain fatty acid (SCFA), body composition, serum and liver lipids, and inflammatory markers in non-alcoholic fatty liver disease (NAFLD) rats. Twenty-four male SD rats were randomly divided into 3 groups: normal control group (standard feed), high-fat diet (HFD) feeding group (83% standard feed + 10% lard oil + 1.5% cholesterol + 0.5% cholate + 5% sucrose), and compound probiotics intervention group (HFD + 0.6 g × kg−1 × d−1 compound probiotics). The microbial population was assessed by 16S rDNA amplification and sequence analysis. Body composition, serum and liver lipids, serum inflammatory markers, colonic SCFAs, and relative proteins were assessed. The results showed that compound probiotics significantly reduced body weight, visceral and total fat mass, and the levels of hepatic TC and TG and serum TG, FFA, ALT, LPS, IL-1β, and IL-18 (P |
| Databáze: | OpenAIRE |
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