Oral antioxidants supplementation for women with unexplained infertility undergoing ICSI/IVF: Randomized controlled trial
| Autor: | Mohamed A. Youssef, Hazem A. Elashmwi, Nevin Elghamary, Dalia Youssef, Ayman N. Raslan, Mohamed N Mohesen, Nadin A. Sherif, Hatem I. Abdelmoty, Aboulfoutouh I. Ismail, Rana Abdella, Ahmed Magdy, Mostafa Abdel Bar, Ahmed S. Ali, Esaad M. Abduljawad, Hisham M. Gouda |
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| Přispěvatelé: | Other departments |
| Rok vydání: | 2014 |
| Předmět: |
Adult
medicine.medical_specialty Pregnancy Rate media_common.quotation_subject medicine.medical_treatment Oocyte Retrieval Fertilization in Vitro Biology Oogenesis Antioxidants law.invention Andrology Ovulation Induction Randomized controlled trial Pregnancy law medicine Humans Sperm Injections Intracytoplasmic Ovulation reproductive and urinary physiology Chelating Agents media_common Unexplained infertility Gynecology urogenital system Female infertility Obstetrics and Gynecology Fertility Agents Female Vitamins General Medicine medicine.disease Combined Modality Therapy Trace Elements Oxidative Stress Pregnancy rate Reproductive Medicine Dietary Supplements embryonic structures Egypt Female Lost to Follow-Up Ovulation induction Infertility Female Follow-Up Studies |
| Zdroj: | Human fertility (Cambridge, England), 18(1), 38-42. Taylor and Francis Ltd. |
| ISSN: | 1742-8149 1464-7273 |
| DOI: | 10.3109/14647273.2014.927595 |
| Popis: | Objective: Good oocyte quality and maturity are important prerequisites for high fertilization and implantation rates in IVF/ ICSI treatment cycles. Reactive oxygen species (ROS) are produced within ovarian follicles, especially during the ovulation process, and increased ROS activity may be a cause of impaired oocyte maturation and higher rate of failure of IVF/ ICSI cycles. Study design: RCT evaluating the effect of antioxidant supplementation on ICSI/IVF outcomes. Two hundred and eighteen women with unexplained subfertility undergoing IVF/ICSI were randomized into two groups. The study group ( n 112) received daily oral antioxidants in the form of multivitamins and minerals (amino acid chelated) while the control group ( n 106) did not. Main outcomes were number of mature metaphase II (MII) oocytes and clinical pregnancy rate. Results: There were no signifi cant changes between the groups as regards age, BMI, basal FSH, number of mature (MII) oocytes (12.7 9.4 vs. 13.2 8.6, P 0.7) and clinical pregnancy rate per woman randomized (38% vs. 34%; [OR 1.2; 95% CI, 0.70 – 2.11]. Conclusion: Oral antioxidants in the form of a combination of multivitamins and minerals (amino acid chelated) did not improve oocyte quality and pregnancy rates in women with unexplained infertility undergoing IVF/ICSI treatment. |
| Databáze: | OpenAIRE |
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