Metformin and Probiotics in the Crosstalk between Colitis-Associated Colorectal Cancer and Diabetes in Mice
| Autor: | David Yannick Leger, Bertrand Liagre, Mona Diab-Assaf, Rosalyn A. Jurjus, Abdo Jurjus, Chawki Boukarim, Sahar Al Kattar, Aline Pinon |
|---|---|
| Přispěvatelé: | PEIRENE (PEIRENE), Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Laboratoire de Chimie des Substances Naturelles (LCSN), Université de Limoges (UNILIM)-Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST FR CNRS 3503), Biochemistry Department, Faculty of Science - Section II, Lebanese UniversityJdeidet, Lebanon |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cancer Research endocrine system diseases Colorectal cancer Inflammation [SDV.CAN]Life Sciences [q-bio]/Cancer colorectal cancer medicine.disease_cause lcsh:RC254-282 Article 03 medical and health sciences 0302 clinical medicine Downregulation and upregulation Diabetes mellitus medicine microbiota oxidative stress Colitis ComputingMilieux_MISCELLANEOUS diabetes business.industry medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens 3. Good health Metformin Crosstalk (biology) 030104 developmental biology Oncology probiotics inflammation 030220 oncology & carcinogenesis Cancer research medicine.symptom business Oxidative stress [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology medicine.drug |
| Zdroj: | Cancers, Vol 12, Iss 1857, p 1857 (2020) Cancers Cancers, MDPI, 2020, 12 (7), pp.1857. ⟨10.3390/cancers12071857⟩ Volume 12 Issue 7 |
| ISSN: | 2072-6694 |
| DOI: | 10.3390/cancers12071857⟩ |
| Popis: | The co-occurrence of colorectal cancer (CRC) and diabetes mellitus along with inflammation and dismicrobism has been frequently reported. Several studies shed light on the antioncogenic potential of metformin on colorectal carcinogenesis. This study aimed to demonstrate that metformin in association with probiotics acts in a synergic effect in breaking the crosstalk, thus inhibiting CRC progression, improving diabetes, and reducing inflammation. Ninety-six male Balb/c mice, 6&ndash 8 weeks old, were divided into 16 control and experimental groups to assess the effect of the different treatments and combinations at the clinical, histological, and molecular levels. Metformin and probiotics showed beneficial outcomes on CRC and diabetes, alone and most importantly in combination. Their effects were exerted by inhibiting the inflammatory process whereby a downregulation of IL-6 and TNF-&alpha as well as oxidative stress were depicted. The characterization of the effects of probiotics and metformin on CRC and diabetes sheds light on the role of inflammation and microbiota in this crosstalk. Deciphering the downstream signaling pathways elicited by these compounds will help in developing new effective targeted treatment modalities. |
| Databáze: | OpenAIRE |
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