Tongue Coating and the Salivary Microbial Communities Vary in Children with Halitosis
| Autor: | Qian Zhang, Xuesong He, Wen Ren, Zhe Xun, Tao Xu, Xuenan Liu, S. Dusko Ehrlich, Nan Qin, Yihong Li, Qun Zhang, Shuguo Zheng, Zicheng Wang, Hui Zheng, Chunyan Wu, Feng Chen, Yifei Zhang, Linshuang Zhang, Ting Chen |
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| Přispěvatelé: | Peking University, Tsinghua University, Realbio Genomics Institute, Partenaires INRAE, Zhejiang University, MetaGenoPolis, Institut National de la Recherche Agronomique (INRA), Centre for Host-Microbiome Interactions, Dental Institute Central Office, King‘s College London, New York University College of Dentistry, NYU System (NYU), School of Dentistry, University of Queensland [Brisbane], University of Southern California (USC), National Natural Science Foundation of China [81200762, 81301475], Peking University School of Stomatology [PKUSS20130210], Scientific Research Foundation for Returned Overseas Chinese Scholars, State Education Ministry, Metagenopolis [ANR-11-DPBS-0001], Ren, Wen, Xun, Zhe |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male Saliva [SDV]Life Sciences [q-bio] Biology Article Microbiology 03 medical and health sciences 0302 clinical medicine volatile sulfur-compounds Tongue hydrogen-sulfide medicine Prevalence Humans Hydrogen Sulfide Child Multidisciplinary Microbiota bacterial-populations Peptostreptococcus stomatis Polyketide metabolism 030206 dentistry Biodiversity Halitosis 3. Good health 030104 developmental biology medicine.anatomical_structure Metagenomics Case-Control Studies Child Preschool Pyrosequencing Metagenome Leptotrichia wadei Female Tongue coating oral malodor general-population |
| Zdroj: | Ren, W, Xun, Z, Wang, Z, Zhang, Q, Liu, X, Zheng, H, Zhang, Q, Zhang, Y, Zhang, L, Wu, C, Zheng, S, Qin, N, Ehrlich, D, Li, Y, He, X, Xu, T, Chen, T & Chen, F 2016, ' Tongue Coating and the Salivary Microbial Communities Vary in Children with Halitosis ', Scientific Reports, vol. 6, 24481 . https://doi.org/10.1038/srep24481 Scientific Reports Scientific Reports, Nature Publishing Group, 2016, 6, pp.1-12. ⟨10.1038/srep24481⟩ Scientific Reports (6), 1-12. (2016) |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/srep24481 |
| Popis: | Halitosis is a common symptom mainly caused by microbial activities in the oral cavity. Here, we used 16S rRNA gene pyrosequencing and metagenomic sequencing to examine oral microbial compositions and their functional variations in children with halitosis. We found that the tongue coating of subjects with halitosis had greater bacterial richness than those of healthy subjects. The relative abundance and prevalence of Leptotrichia wadei and Peptostreptococcus stomatis were higher in tongue coating samples from children with halitosis than those from children without halitosis; Prevotella shahii had higher relative abundance and prevalence in saliva samples from children with halitosis. We present the first comprehensive evaluation of the co-occurrence networks of saliva and tongue coating communities under healthy and halitosis conditions and investigated patterns of significant differences between these communities. Moreover, we observed that bacterial genes associated with responses to infectious diseases and terpenoid and polyketide metabolism were enriched in subjects with halitosis, but not in healthy subjects. Hydrogen sulphide (H2S)-related metabolic pathways suggested that there was higher microbial production and less usage of H2S in subjects with halitosis. Thus, the mechanism of halitosis was implied for the first time via metagenomic sequencing. |
| Databáze: | OpenAIRE |
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