Hyaluronan Can Be Protected from Free-Radical Depolymerization by 2,6-Diisopropylphenol, a Novel Radical Scavenger
| Autor: | C Kvam, D Granese, Piero Pollesello, Antonella Flaibani, Sergio Paoletti |
|---|---|
| Přispěvatelé: | Kvam, C, Granese, D, Flaibani, A, Pollesello, P, Paoletti, Sergio |
| Jazyk: | angličtina |
| Rok vydání: | 1993 |
| Předmět: |
Time Factors
Antioxidant Free Radicals Macromolecular Substances Radical medicine.medical_treatment Biophysics Biochemistry chemistry.chemical_compound Hyaluronic acid Hydroxides medicine Synovial fluid Hyaluronic Acid Xanthine oxidase Propofol Molecular Biology Hydroxyl Radical Chemistry Depolymerization Free Radical Scavengers Cell Biology Scavenger (chemistry) Kinetics Chromatography Gel Hydroxyl radical |
| Popis: | The scavenging effect of 2,6-diisopropylphenol on hydroxy radicals produced by xanthine oxidase was assessed by evaluating the in vitro depolymerisation of hyaluronan in artificial synovial fluid by size-exclusion chromatography. After 1 hour, the number-average molecular weight of hyaluronan remained unchanged (100%) with 2,6-diisopropylphenol, whereas it dropped to 90% with methylprednisolone added, to 55% with the antioxidant 2,6-tert-butyl-4-methylphenol added, and to 10% of its initial value in the absence of scavenger. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|