Anaphylactic IgE and IgG1production for hapten can be enhanced by contrast media
| Autor: | C Ushiyama, H Katayama, T Miyauchi, K Okumura, Z Ovary, Takao Hirano |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Immunogen
medicine.medical_treatment Contrast Media Enzyme-Linked Immunosorbent Assay Immunoglobulin E Mice Immune system Animals Medicine Radiology Nuclear Medicine and imaging Anaphylaxis Mice Inbred BALB C biology business.industry General Medicine medicine.disease Iopamidol Disease Models Animal Immunoglobulin G Hemocyanins Monoclonal Immunology biology.protein Female Antibody business Hapten Adjuvant Spleen |
| Zdroj: | The British Journal of Radiology. 69:920-924 |
| ISSN: | 1748-880X 0007-1285 |
| DOI: | 10.1259/0007-1285-69-826-920 |
| Popis: | Various side effects have been associated with the clinical use of contrast media. Immunological mechanisms have been proposed but there have been very few experimental studies with animal models. We have attempted to develop murine models to determine whether or not anaphylactic antibodies such as IgE and IgG1 against hapten (DNP) were enhanced with contrast medium (iopamidol) as an adjuvant or if the contrast medium itself produced antibodies of the IgE class. The results showed that anti-hapten IgE and IgG1 production was greatly enhanced with immunogen plus contrast medium. Anti-contrast medium antibodies of the IgE class could not be detected by PCA reactions. The enhancement of IgE and IgG1 production for hapten was associated with IL-4 release by the neutralization test used by monoclonal anti-IL-4 antibodies. This is the first observation to show that contrast media may have a strong adjuvant effect for the production of IgE and IgG1. This murine model demonstrates a possible immunological function of contrast media in vivo. |
| Databáze: | OpenAIRE |
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