False Negative Toxoplasma Serology in an Immunocompromised Patient with PCR Positive Ocular Toxoplasmosis
| Autor: | Philip I. Murray, Alastair K Denniston, Rehan Rajput |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
genetic structures Antibodies Protozoan Enzyme-Linked Immunosorbent Assay Real-Time Polymerase Chain Reaction Antiviral Agents Serology Aqueous Humor 03 medical and health sciences Immunocompromised Host 0302 clinical medicine Predictive Value of Tests hemic and lymphatic diseases Trimethoprim Sulfamethoxazole Drug Combination medicine Immunology and Allergy Humans Valganciclovir Toxoplasmosis Ocular False Negative Reactions Retrospective Studies biology business.industry Chorioretinitis DNA Protozoan Middle Aged medicine.disease eye diseases Toxoplasmosis Toxoplasma serology Anti-Bacterial Agents Vitreous Body Ophthalmology Drug Combinations Real-time polymerase chain reaction Immunoglobulin M 030220 oncology & carcinogenesis Intraocular fluid Immunoglobulin G Immunology 030221 ophthalmology & optometry biology.protein sense organs Antibody Complication business Toxoplasma |
| Zdroj: | Ocular immunology and inflammation. 26(8) |
| ISSN: | 1744-5078 |
| Popis: | Purpose: The authors report a case of a 60-year-old Caucasian male with a background of treated Chronic Lymphocytic Leukaemia (CLL) with secondary hypogammaglobulinaemia present with toxoplasma chorioretinitis and negative serum toxoplasma serology on presentation and on subsequent reactivation.Methods: Retrospective case notes review with fundal photographs.Results: In this case, on initial presentation and on recurrence, the patient’s serum anti-Toxoplasma IgG remained negative. The diagnosis was made on quantitative PCR of vitreous initially and aqueous humor on reactivation.Conclusions: Despite negative serology, one must still consider ocular toxoplasmosis especially in CLL patients where the clinical picture could be compatible. Hypogammaglobulinaemia, the inability to produce IgG antibodies, is a well-recognized complication of CLL. Intraocular fluid sampling is essential in these cases where the sensitivity of PCR on either aqueous or vitreous humor has been shown to be higher in immunocom... |
| Databáze: | OpenAIRE |
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