Nitroso-oxidative stress after activation of 5-HT4 receptors under conditions of colitis in rats
| Autor: | Alexander Sklyarov, Nataliya Denysenko, Iryna Fomenko, Vitaliy Yemelyanenko |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
mosapride experimental colitis no-synthase Pharmacology toxicology Pharmacy Pharmacology medicine.disease_cause Biochemistry 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine antioxidant enzymes medicine Colitis Receptor Molecular Biology business.industry lipid peroxidation General Medicine Nitroso medicine.disease 030104 developmental biology chemistry Medicine 030211 gastroenterology & hepatology business Oxidative stress |
| Zdroj: | Current Issues in Pharmacy and Medical Sciences, Vol 32, Iss 2, Pp 57-62 (2019) |
| ISSN: | 2300-6676 2084-980X |
| DOI: | 10.2478/cipms-2019-0011 |
| Popis: | Serotonin (5-hydroxytryptamine, 5-HT) plays an important role in the regulation of the functioning of the gastrointestinal tract, including that of the colon. The response of smooth muscles, blood vessels and colon mucosa (CM) to 5-HT is realized through the activation of various types of 5-HT receptors, in particular, 5-HT4 receptors, since the latter are identified on colon cells membranes (enterocytes, smooth muscles and endothelium). The aim of our study was to determine the effect of 5-НT4 receptors agonist (mosapride) on nitrogen (II) oxide production and lipid peroxidation in CM and colon muscle tissue (CMT) under the conditions of experimental ulcerative colitis (UC). |
| Databáze: | OpenAIRE |
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