Physicochemical properties and biological activities of novel blend films using oxidized pectin/chitosan
| Autor: | Meriem Elkolli, Nadège Follain, Stéphane Marais, Didier Le Cerf, Mahmoud Bounekhel, Asma Chetouani, Djafer Benachour, Christophe Rihouey |
|---|---|
| Přispěvatelé: | Université Ferhat-Abbas Sétif 1 [Sétif] (UFAS1), Polymères Biopolymères Surfaces (PBS), Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut de Chimie du CNRS (INC)-Institut Normand de Chimie Moléculaire Médicinale et Macromoléculaire (INC3M), Institut de Chimie du CNRS (INC)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Université Le Havre Normandie (ULH), Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Université Le Havre Normandie (ULH), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
food.ingredient
Chemical Phenomena Biocompatibility Pectin Size-exclusion chromatography 02 engineering and technology macromolecular substances 010402 general chemistry Hemolysis 01 natural sciences Biochemistry Chitosan Biomaterials chemistry.chemical_compound food Differential scanning calorimetry Structural Biology Oxidation Humans Organic chemistry Molecular Biology Schiff Bases Sodium periodate Periodate General Medicine [CHIM.MATE]Chemical Sciences/Material chemistry 021001 nanoscience & nanotechnology Haemolysis Anti-Bacterial Agents 0104 chemical sciences Molecular Weight carbohydrates (lipids) [CHIM.POLY]Chemical Sciences/Polymers chemistry Pectins Antibacterial activity Blood compatibility 0210 nano-technology Oxidation-Reduction Nuclear chemistry |
| Zdroj: | International Journal of Biological Macromolecules International Journal of Biological Macromolecules, Elsevier, 2017, 97, pp.348-356. ⟨10.1016/j.ijbiomac.2017.01.018⟩ |
| ISSN: | 0141-8130 |
| DOI: | 10.1016/j.ijbiomac.2017.01.018⟩ |
| Popis: | International audience; Pectin has been widely used in a variety of biomedical applications. In this study, it was modified with sodium periodate as an oxidant and characterized by physicochemical methods Periodate oxidation increased the contents of dialdehyde units and carboxyl groups in pectin, and a decrease in pectin viscosity was measured. The oxidization reaction led to a significant decrease in all values of molecular weight and size (Mn, Mw, [η] and Rh) as determined by size exclusion chromatography (SEC), which allowed the selection of the oxidized pectin to be added to chitosan. Chitosan-based films were characterized by infra-red spectroscopy (FTIR), X-ray diffractometry (XRD), and differential scanning calorimetry (DSC) measurements. Thermal behaviour studies demonstrated that interactions existed between chitosan and oxidized pectin. The haemolysis percentages of films were found to be less than 5%, which indicated their good blood compatibility. Finally, the antibacterial activity was clearly improved. Cross-linking reactions between pectin and chitosan through ionic bonds and amide bonds and between chitosan and oxidized pectin through Schiff base formation were evidenced, which opens the way to extend applications of these polysaccharides; notably, the biocompatibility and biodegradability of these new networks is convenient for pharmaceutical, biomedical or cosmetic applications. |
| Databáze: | OpenAIRE |
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