Loss of microRNA-200a and c, and microRNA-203 expression at the invasive front of primary cutaneous melanoma is associated with increased thickness and disease progression
| Autor: | Karin van den Hurk, Alan Spatz, Véronique Winnepenninckx, Joost van den Oord, Marguerite Stas, Stefan Michiels, Léon C van Kempen, Vladimir Lazar |
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| Přispěvatelé: | RS: GROW - R2 - Basic and Translational Cancer Biology, Pathologie, RS: CARIM School for Cardiovascular Diseases |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Pathology
medicine.medical_specialty Skin Neoplasms Down-Regulation In situ hybridization Melanoma thickness Biology Pathology and Forensic Medicine Melanoma progression Text mining Predictive Value of Tests microRNA medicine Biomarkers Tumor Humans Molecular Biology Melanoma Retrospective Studies MicroRNA 200 family Cadherin business.industry E-cadherin Cell Biology General Medicine medicine.disease Cadherins Prognosis Gene Expression Regulation Neoplastic MicroRNAs Tumor progression Cutaneous melanoma Disease Progression Immunohistochemistry business Mesenchymal characteristics |
| Zdroj: | Virchows Archiv, 461(4), 441-448. Springer, Cham |
| ISSN: | 0945-6317 |
| Popis: | Loss of E-cadherin expression in melanoma correlates with increased tumor thickness and reduced disease-free survival. The molecular mechanisms underpinning its differential expression in melanoma tissue remain elusive. MicroRNAs (miRNAs) have been implicated in tumor progression and regulation of E-cadherin expression. Here, we demonstrate a significant correlation between tumor thickness and loss of expression of miR-200a, miR-200c, and miR-203 in a series of 23 frozen primary melanomas, where it was confirmed in two subsequent validation series (series 1: six nevi, 15 primary melanomas, and 16 metastases; series 2: 11 matched pairs of primary melanomas and metastases). Decreased levels of miR-200a, miR-200c, and miR-203 correlated with increasing thickness in the combined validation series (P = 0.024, 0.033, and 0.031, respectively). In addition, progressive loss of miR-200a expression with disease progression was observed in series 1 (P |
| Databáze: | OpenAIRE |
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