Pathogenesis of Junonia coenia densovirus in Spodoptera frugiperda: A route of infection that leads to hypoxia
| Autor: | Philippe Fournier, Béatrice Chabi, Mylène Ogliastro, Jean-Michel Salmon, Doriane Mutuel, Marc Ravallec, Cecilia Multeau |
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| Přispěvatelé: | Biologie Intégrative et Virologie des Insectes [Univ. de Montpellier II] (BIVI), Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de la Recherche Agronomique (INRA), Différenciation Cellulaire et Croissance (DCC), Institut National de la Recherche Agronomique (INRA)-Université Montpellier 2 - Sciences et Techniques (UM2), Biotop, Sciences Pour l'Oenologie (SPO), Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Université Montpellier 1 (UM1)-Université de Montpellier (UM)-Institut National de la Recherche Agronomique (INRA) |
| Rok vydání: | 2010 |
| Předmět: |
ANOXIA
[SDV]Life Sciences [q-bio] PATHOGENESIS Spodoptera Biology Virus Pathogenesis 03 medical and health sciences INSECT PARVOVIRUS Virology [SDV.IDA]Life Sciences [q-bio]/Food engineering TISSUE TROPISM medicine Animals [INFO]Computer Science [cs] [SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering SPODOPTERA FRUGIPERDA Barrier function 030304 developmental biology DENSOVIRUS 0303 health sciences 030306 microbiology HOST RANGE fungi ROS Midgut RELATION VIRUS-VECTEUR biology.organism_classification INSECT TRACHEA Epithelium 3. Good health Oxygen Trachea Oxidative Stress medicine.anatomical_structure Larva Tissue tropism Densovirus BIOLOGICAL CONTROL |
| Zdroj: | Virology Virology, Elsevier, 2010, 403 (2), pp.137-144. ⟨10.1016/j.virol.2010.04.003⟩ |
| ISSN: | 0042-6822 1096-0341 |
| DOI: | 10.1016/j.virol.2010.04.003 |
| Popis: | International audience; To evaluate densovirus potential against lepidopteran pests and their capacity to invade new hosts, we have characterised in vivo the infection and pathogenesis of the Junonia coenia densovirus (JcDNV) in the noctuid pest Spodoptera frugiperda. Here we show that infection starts with the ingestion of viral particles that cross the midgut epithelium without replicating. By quantitative PCR we established the kinetic and the route of infection, from virus ingestion to replication in visceral tracheae and hemocytes. JcDNV has a high particle-to-infection ratio mostly due to the barrier function of the midgut. Pathology and cytopathology suggested that infection of tracheal cells impairs oxygen delivery to demanding tissues leading to cytopathic effects in all the tissues. Finally, larval death results from several physiological shocks, including molting arrest and anoxia. |
| Databáze: | OpenAIRE |
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